A new look at experimental herpes simplex eye disease: preliminary results of clinical disease in the NIH mouse after zosteriform spread.

Following the discovery by Tullo et al that herpes simplex virus type 1 (HSV1) can reach the eye by zosteriform spread after inoculation into the cutaneous field of the trigeminal ganglion, this model has been adapted to the NIH strain of inbred mouse. Clinical disease in the NIH mouse after snout inoculation includes skin disease, mydriasis, iritis and keratitis.