Medical Imaging Center - CT Room, The 3rd Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, Xinjiang, China.
Department of Radiology, Bethune International Peace Hospital of PLA, Shijiazhuang, Hebei Province, China.
Medicine (Baltimore). 2021 Sep 17;100(37):e27044. doi: 10.1097/MD.0000000000027044.
The purpose of this retrospective study was to explore the advantages of computed tomography (CT) nano-contrast agent in tumor diagnosis.A total of 100 patients with malignant tumor who were diagnosed in Shaanxi Province Public Hospital between January 2018 and January 2019 were included in this retrospective study. They were randomly divided into observation and control groups with 50 patients in each group. The patients in the observation group used new type of nano-contrast agent for examination, and the patients in the control group used traditional iohexol contrast agent for examination. The detection rate, misdiagnosis rate, and incidence of adverse reactions were observed. In addition, single photon emission computed tomography or CT scan was performed on patients to observe the radioactive concentration.The detection rate was 100% in the observation group and 84% in the control group, and the difference between the 2 groups was statistically significant (χ2 = 8.763, P = .001). The incidence of adverse reactions was 2% in the observation group and 30% in the control group, and the difference between the 2 groups was significantly different (χ2 = 12.683, P = .000). The radioactive concentration in the observation group was markedly higher than that in the control group (t = 19.692, P = .001).The use of CT nano-contrast agent in tumor diagnosis had higher detection rate of tumor and radioactive concentration, and it had lower misdiagnosis rate and adverse reaction rate than traditional iohexol contrast agent.
本回顾性研究旨在探讨计算机断层扫描（CT）纳米造影剂在肿瘤诊断中的优势。共纳入 2018 年 1 月至 2019 年 1 月在陕西省公立医院诊断为恶性肿瘤的 100 例患者，将其随机分为观察组和对照组，每组 50 例。观察组患者采用新型纳米造影剂检查，对照组患者采用传统碘海醇造影剂检查。观察两组患者的检出率、误诊率和不良反应发生率。此外，对患者进行单光子发射计算机断层扫描或 CT 扫描，观察放射性浓度。观察组的检出率为 100%，对照组为 84%，两组比较差异有统计学意义（χ2=8.763，P=0.001）。观察组不良反应发生率为 2%，对照组为 30%，两组比较差异有统计学意义（χ2=12.683，P=0.000）。观察组放射性浓度明显高于对照组（t=19.692，P=0.001）。CT 纳米造影剂在肿瘤诊断中的应用具有更高的肿瘤检出率和放射性浓度，误诊率和不良反应发生率低于传统碘海醇造影剂。
