咖啡饮用与降低慢性肾脏病发病风险相关：系统评价和荟萃分析方案。
Coffee consumption is associated with a decreased risk of incident chronic kidney disease: A protocol for systematic review and meta-analysis.
机构信息
Department of General Medicine, Wuliqiao Community Health Center, Huangpu District, Shanghai, China.
Department of Internal Medicine, Shanghai Xinqidian Rehabilitation Hospital, Shanghai, China.
出版信息
Medicine (Baltimore). 2021 Sep 17;100(37):e27149. doi: 10.1097/MD.0000000000027149.
BACKGROUND
Recent studies have suggested a renal protective effect of coffee consumption against development of chronic kidney disease (CKD), although the results remain inconclusive. We performed a protocol for systematic review and meta-analysis to comprehensively investigate this association by summarizing all available data.
METHODS
An all-round retrieval will be performed in 5 electronic journal databases from their inception to June 2021, which comprise Medline, PubMed, Embase, ScienceDirect, and the Cochrane Library. The following key words were used on combination with Boolean operators AND or OR: "coffee," "caffeine," "renal insufficiency," "chronic kidney diseases," "chronic renal diseases." Two authors completed the quality assessment using the Newcastle-Ottawa Scale for observational studies. The meta-analysis was conducted using Review Manager 5.3 software from the Cochrane Collaboration (London, UK).
RESULTS
The findings of this study will be submitted to peer-reviewed journals for publication.
CONCLUSION
Coffee consumption may be associated with a lower risk of incident CKD.
背景
最近的研究表明，咖啡的摄入对慢性肾脏病（CKD）的发展具有肾脏保护作用，尽管结果仍不确定。我们制定了一个系统评价和荟萃分析的方案，通过总结所有可用的数据，全面调查这种相关性。
方法
将从各数据库建库起至 2021 年 6 月，全面检索 5 个电子期刊数据库，包括 Medline、PubMed、Embase、ScienceDirect 和 Cochrane Library。使用以下关键词组合并使用逻辑运算符 AND 或 OR：“coffee”、“caffeine”、“renal insufficiency”、“chronic kidney diseases”、“chronic renal diseases”。两位作者使用纽卡斯尔-渥太华量表（Newcastle-Ottawa Scale）对观察性研究进行质量评估。荟萃分析使用 Cochrane 协作网（英国伦敦）的 Review Manager 5.3 软件进行。
结果
本研究的结果将提交给同行评议的期刊发表。
结论
咖啡的摄入可能与较低的 CKD 发病风险相关。
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