Emergency Department, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China.
General Medical Department, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China.
Medicine (Baltimore). 2021 Sep 17;100(37):e27196. doi: 10.1097/MD.0000000000027196.
Sepsis is a syndrome of infection-induced systemic inflammatory response. Conventional treatment combined with Shenfu injection (SFI) has been previously validated clinical effective in alleviating inflammatory response in patients with septic shock. However, evidence-based medical evidence is scant. Herein, we designed the protocol of a proposed study based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, aiming to systematically evaluate the efficacy and safety of SFI in patients with sepsis.
Eligible studies reporting the efficacy and safety of SFI in the treatment of sepsis published before August 2021 will be searched from online databases, including the PubMed, Web of Science, EMBASE, Ovid, the Cochrane Library, Wanfang Database, China National Knowledge Infrastructure, and China Biology Medicine Disc. The literature selection process will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. After data extraction and methodological quality evaluation, Stata 12.0 software will be used to synthesize the data through fixed/random effects of meta-analysis models.
The results of this meta-analysis will be submitted to a peer-reviewed journal for publication.
This study will provide reliable evidence-based basis for the clinical application of SFI in the treatment of sepsis.
DOI 10.17605/OSF.IO/KCMDQ.
败血症是一种感染引起的全身炎症反应综合征。常规治疗联合参附注射液（SFI）已被证实可有效缓解感染性休克患者的炎症反应。然而，目前缺乏循证医学证据。本研究旨在基于系统评价和荟萃分析的首选报告项目指南制定研究方案，以系统评价 SFI 治疗败血症患者的疗效和安全性。
我们将检索 2021 年 8 月前发表的关于 SFI 治疗败血症的疗效和安全性的研究，检索数据库包括 PubMed、Web of Science、EMBASE、Ovid、Cochrane 图书馆、万方数据库、中国知网和中国生物医学文献数据库。文献筛选过程将按照系统评价和荟萃分析的首选报告项目指南进行报告。提取数据和评价方法学质量后，采用 Stata 12.0 软件通过固定/随机效应模型进行荟萃分析。
本荟萃分析的结果将提交给同行评议期刊发表。
本研究将为 SFI 治疗败血症的临床应用提供可靠的循证医学依据。
OSF 注册号：DOI 10.17605/OSF.IO/KCMDQ。
