头发皮质醇、肥胖与免疫系统：一项为期3年的纵向研究结果。
Hair cortisol, obesity and the immune system: Results from a 3 year longitudinal study.
作者信息
van der Valk Eline S, van der Voorn Bibian, Iyer Anand M, Mohseni Mostafa, Leenen Pieter J M, Dik Willem A, van den Berg Sjoerd A A, de Rijke Yolanda B, van den Akker Erica L T, Penninx Brenda W J H, van Rossum Elisabeth F C
机构信息
Obesity Centre CGG, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Obesity Centre CGG, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
出版信息
Psychoneuroendocrinology. 2021 Sep 25;134:105422. doi: 10.1016/j.psyneuen.2021.105422.
OBJECTIVES
Higher long-term glucocorticoid levels, measured in scalp hair (HairGC), are associated with obesity. This may represent the state of obesity (perhaps interrelated with chronic immune activation), but could also promote further weight gain. We studied whether hair cortisol (HairF) and hair cortisone (HairE) predict changes in body mass index (BMI) and waist circumference (WC) over time, and assessed the association between HairGC and common immune parameters.
METHODS
We measured HairGC in 1604 participants of the Netherlands Study of Depression and Anxiety (NESDA), and investigated their associations to BMI, WC, and immune parameters (interleukin-6 (IL-6), C-reactive protein (CRP), and leukocyte subsets). Also, we assessed whether baseline HairGC predict changes in BMI and WC at follow-up (three years later).
RESULTS
In cross-sectional analyses, HairF and HairE were positively associated to BMI (β = 2.06 kg/m, 95% confidence interval (CI)= 1.22-2.90 kg/m) and β = 2.84 kg/m (95%CI 1.75-3.93 kg/m) respectively) and WC (β = 5.36 cm (95%CI 3.09-7.62 cm) and β = 8.54 cm (95%CI 5.60-11.48 cm) respectively, all p < 0.001). HairF was also positively associated to IL-6 (β = 0.15 (95%CI 0.003-0.292) p < 0.05) and leukocyte count (β = 0.57 (95%CI 0.234-0.909), p < 0.01), and HairE to IL-6 (β = 0.21 (95%CI 0.016-0.399), p < 0.05). In the longitudinal analyses, higher HairF was associated with yearly increases in BMI (β = 0.58% BMI change per year (95%CI 0.14-1.01%), p = 0.009) and higher HairE with increases in WC (β = 0.84% WC change per year (95%CI 0.02-1.69%), p = 0.049). Adjusting for baseline IL-6 or leukocytes did not change the found associations between HairGC and WC or BMI change.
CONCLUSIONS
HairGC levels are positively associated to BMI, WC, IL-6 and leukocyte numbers in cross-sectional analyses, and to increases in BMI and WC in longitudinal analyses. Although causality is yet to be proven, higher long-term glucocorticoid levels could represent a relevant risk factor for the development of obesity.
目的
头皮毛发中测得的较高长期糖皮质激素水平（毛发糖皮质激素，HairGC）与肥胖相关。这可能代表肥胖状态（或许与慢性免疫激活相关），但也可能促进体重进一步增加。我们研究了毛发皮质醇（HairF）和毛发可的松（HairE）是否能预测体重指数（BMI）和腰围（WC）随时间的变化，并评估了HairGC与常见免疫参数之间的关联。
方法
我们在荷兰抑郁与焦虑研究（NESDA）的1604名参与者中测量了HairGC，并研究了其与BMI、WC和免疫参数（白细胞介素-6（IL-6）、C反应蛋白（CRP）和白细胞亚群）的关联。此外，我们评估了基线HairGC是否能预测随访时（三年后）BMI和WC的变化。
结果
在横断面分析中，HairF和HairE分别与BMI呈正相关（β = 2.06 kg/m，95%置信区间（CI）= 1.22 - 2.90 kg/m）和β = 2.84 kg/m（95%CI 1.75 - 3.93 kg/m），与WC也呈正相关（β = 5.36 cm（95%CI 3.09 - 7.62 cm）和β = 8.54 cm（95%CI 5.60 - 11.48 cm），所有p < 0.001）。HairF还与IL-6呈正相关（β = 0.15（95%CI 0.003 - 0.292），p < 0.05）和白细胞计数呈正相关（β = 0.57（95%CI 0.234 - 0.909），p < 0.01），HairE与IL-6呈正相关（β = 0.21（95%CI 0.016 - 0.399），p < 0.05）。在纵向分析中，较高的HairF与BMI的年增加相关（β = 每年0.58%的BMI变化（95%CI 0.14 - 1.01%），p = 0.009），较高的HairE与WC的增加相关（β = 每年0.84%的WC变化（95%CI 0.02 - 1.69%），p = 0.049）。调整基线IL-6或白细胞后，HairGC与WC或BMI变化之间的已发现关联未改变。
结论
在横断面分析中，HairGC水平与BMI、WC、IL-6和白细胞数量呈正相关，在纵向分析中与BMI和WC的增加呈正相关。尽管因果关系尚待证实，但较高的长期糖皮质激素水平可能是肥胖发生的一个相关危险因素。
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