膳食糖尿病风险降低评分及其成分与德黑兰成年人代谢综合征发病风险的关联。

The association of dietary diabetes risk reduction score and its components with risk of metabolic syndrome incident in Tehranian adults.

机构信息

Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

出版信息

BMC Endocr Disord. 2021 Oct 20;21(1):206. doi: 10.1186/s12902-021-00872-w.

DOI:10.1186/s12902-021-00872-w

PMID:34666751

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8527668/

Abstract

BACKGROUND

Evidence of possible beneficial effects of dietary diabetes risk reduction score (DDRRS) on reducing the risk of various chronic diseases such as metabolic syndrome (MetS) are limited. This is a prospective, population-based cohort study, which aimed to investigate the relationship of the DDRRS and its components with MetS incident in Iranian adults.

METHODS

Individuals without MetS (n=3561) were recruited from participants of the Tehran Lipid and Glucose Study (2009-2011) and followed for a mean of 6.01 years. A validated food frequency questionnaire was used to determine the DDRRS using based on eight components, including higher intakes of cereal fiber, nuts, coffee, and polyunsaturated: saturated fat ratio and lower intakes of red or processed meats, sugar-sweetened beverages, trans fatty acids, and low glycemic index. We used the multivariable logistic regression analysis to determine the odds ratio (ORs) and 95 % confidence interval (CI) of MetS across the tertiles of DDRRS.

RESULTS

The mean (SD) age of individuals was 38.1(12.6) years at baseline. Median (25-75 interquartile range) DDRRS for all participants was 20(18-22). During the study follow-up, 682(19.1 %) new cases of MetS were reported. Based on the age and sex-adjusted model, participants in highest tertile of DDRRS had lower risk of MetS in compared with the lowest one (OR=0.64;95 %CI:0.52-0.79, P for trend=0.001). In the multivariable adjusted model, after adjustment for all possible confounding variables, the risk of MetS is decreased across tertiles of DDRRS (OR=0.60;95 %CI:0.48-0.75, P for trend=0.001). Also, higher scores of some DDRRS components including red and processed meat, sugar sweetened beverages, and coffee were related to decreased incidence of MetS.

CONCLUSIONS

The results of this study revealed that greater adherence to DDRRS can be associated with decreased risk of MetS in Iranian adult.

摘要

背景

饮食糖尿病风险降低评分（DDRRS）对降低代谢综合征（MetS）等各种慢性疾病风险的可能有益影响的证据有限。这是一项前瞻性、基于人群的队列研究，旨在调查 DDRRS 及其成分与伊朗成年人 MetS 发病的关系。

方法

从 2009-2011 年参加德黑兰血脂和血糖研究的无 MetS 个体（n=3561）中招募参与者，并进行了平均 6.01 年的随访。使用经过验证的食物频率问卷，基于 8 个成分确定 DDRRS，包括更高的谷物纤维、坚果、咖啡和多不饱和：饱和脂肪比以及更低的摄入红肉或加工肉、含糖饮料、反式脂肪酸和低血糖指数。我们使用多变量逻辑回归分析来确定 DDRRS 三分位数与 MetS 的比值比（OR）和 95%置信区间（CI）。

结果

个体的平均（SD）年龄在基线时为 38.1(12.6)岁。所有参与者的中位数（25-75 分位间距）DDRRS 为 20(18-22)。在研究随访期间，报告了 682(19.1%)例新的 MetS 病例。在年龄和性别调整模型中，与最低 tertile 相比，最高 tertile 的 DDRRS 参与者患 MetS 的风险较低（OR=0.64；95%CI：0.52-0.79，P 趋势=0.001）。在多变量调整模型中，在调整所有可能的混杂变量后，DDRRS 三分位数与 MetS 风险降低相关（OR=0.60；95%CI：0.48-0.75，P 趋势=0.001）。此外，DDRRS 某些成分的得分较高，包括红肉和加工肉、含糖饮料和咖啡，与 MetS 的发生率降低有关。