Leetanaporn Kittinun, Hanprasertpong Jitti, Navakanitworakul Raphatphorn
Department of Biomedical Sciences and Biomedical Engineering.
Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Oncol Rev. 2021 Sep 21;15(2):542. doi: 10.4081/oncol.2021.542.
Cell-to-cell communication is a pivotal aspect of cancer biology. Recently, extracellular vesicles (EVs)have been shown to play essential roles in intercellular communications between cancer cells and the surrounding microenvironment owing to cancer development. EVs are small membrane-bound vesicles secreted by various cells containing proteins, lipids, mRNAs, and non-coding RNAs (microRNAs and long non-coding RNAs), which contribute to cancer cell development and progression. Here, we provide an overview of current research direction on EVs, especially biomolecules in EVs, and also point out the novel diagnostics, monitoring, predicting, and therapeutic aspects using EVs against cancer.
细胞间通讯是癌症生物学的一个关键方面。最近，细胞外囊泡（EVs）已被证明由于癌症发展而在癌细胞与周围微环境之间的细胞间通讯中发挥重要作用。EVs是由各种细胞分泌的小膜结合囊泡，含有蛋白质、脂质、mRNA和非编码RNA（微小RNA和长链非编码RNA），它们有助于癌细胞的发育和进展。在此，我们概述了当前关于EVs的研究方向，特别是EVs中的生物分子，并指出了使用EVs对抗癌症的新型诊断、监测、预测和治疗方面。
