Pierre Fabre Dermo-Cosmétique, Toulouse, France.
Medical Affairs Department, Pierre Fabre Laboratory, Lavaur, France.
J Eur Acad Dermatol Venereol. 2021 Nov;35 Suppl 2:12-20. doi: 10.1111/jdv.17245.
Telogen effluvium is a hair loss disorder occurring about 3 months after a triggering event. The acute form impairs quality of life, but spontaneous recovery usually begins 3-6 months after identification and elimination of the cause, with complete recovery taking around 12 months.
To investigate the effectiveness and safety of a hair lotion containing creatine, acetyl tetrapeptide-2 and B vitamins for reducing hair loss in acute telogen effluvium.
In this open, randomized, controlled study (NCT04652232), women with acute telogen effluvium from two clinical centres were randomly allocated to receive either the lotion and a mild shampoo (intervention group), or the mild shampoo alone (controls). Hair growth parameters and hair loss were measured from phototrichograms at weeks (W) 1, 4, 8 and 16, and through investigator assessments of standardized photographs at W1 and W16. The primary criterion was the change in anagen to telogen (A/T) ratio between W1 and W16.
One hundred women (aged 19-50 years) were included (intervention group, N = 51; controls, N = 49). Compared to baseline, the A/T ratio was higher at W16 in both groups and was significantly higher at both W4 and W8 in the intervention group, compared to only at W8 in controls. Significant decreases in telogen hair density were seen at all time points in the intervention group, compared to only at W16 in controls, and the between-group difference was significant at W8 (P = 0.0465). A larger reduction in the total number of hairs shed was observed at W8 in the intervention group (P = 0.0392). Investigator-assessed scores showed improvements in hair density for the intervention group. Global tolerance of the lotion was excellent.
The lotion tested had a significant impact on hair loss in women with acute telogen effluvium and appeared to accelerate recovery from this condition.
休止期脱发是一种脱发疾病，通常在触发事件发生后 3 个月出现。急性形式会降低生活质量，但自发恢复通常在确定和消除病因后 3-6 个月开始，完全恢复需要大约 12 个月。
研究一种含有肌酸、乙酰四肽-2 和 B 族维生素的头发洗剂在减少急性休止期脱发中的脱发的有效性和安全性。
在这项开放、随机、对照研究（NCT04652232）中，来自两个临床中心的急性休止期脱发女性患者被随机分配接受洗剂和温和洗发水（干预组）或仅接受温和洗发水（对照组）。从周（W）1、4、8 和 16 的毛发照相术和 W1 和 W16 的研究者评估的标准化照片测量头发生长参数和脱发情况。主要标准是 W1 和 W16 之间的生长期到休止期（A/T）比值的变化。
共有 100 名女性（年龄 19-50 岁）入组（干预组，N=51；对照组，N=49）。与基线相比，两组在 W16 时 A/T 比值均升高，且干预组在 W4 和 W8 时均显著高于对照组仅在 W8 时。与对照组仅在 W16 时相比，干预组在所有时间点的休止期头发密度均显著下降，且组间差异在 W8 时具有统计学意义（P=0.0465）。在 W8 时，干预组脱落的总发量减少更为明显（P=0.0392）。研究者评估的评分显示干预组的头发密度有所改善。对洗剂的总体耐受性良好。
测试的洗剂对急性休止期脱发女性的脱发有显著影响，并似乎加速了这种情况的恢复。
