Anzai Alessandra, Pereira Amanda F, Malaquias Kleber R, Guerra Lucas O, Mercuri Maurízio
Private Practice, São Paulo, SP, Brazil.
Hypera Pharma, São Paulo, SP, Brazil.
Dermatol Ther. 2020 May;33(3):e13293. doi: 10.1111/dth.13293. Epub 2020 Mar 20.
Androgenetic alopecia (AGA) and telogen effluvium (TE) are common causes of hair loss, with limited options for treatment. The aim of this study was to determine the efficacy and safety of a new formulation kit (Pielus Anti-hair loss lotion and shampoo) containing anti-inflammatory and antioxidant agents in patients with TE and/or AGA. This was a prospective, single-arm, open-label study with 35 women and 10 men, median age of 44 years, with clinical diagnosis of TE and/or AGA. They used the combination of shampoo and lotion daily for 90 days. There was nonoccurrence of adverse events. Phototricogram showed increase in the average number of anagen hairs at T90 (P < .001). Scalp microphotography showed increase in total follicular units, total of hairs, and median hair per follicle unit at T90. There was an increase in diameter (P = .003) and in median maximum load and resistance to traction in T90 (P = .040). Combing and washing test demonstrated a decrease in the number of shed hairs before washing (P = .005), after washing (P = .01) and in total (P < .001). The use of shampoo+ lotion daily was safe and effective to attenuate hair loss in men and women with TE and/or AGA.
雄激素性脱发（AGA）和休止期脱发（TE）是常见的脱发原因，治疗选择有限。本研究的目的是确定一种含有抗炎和抗氧化剂的新配方套装（Pielus抗脱发乳液和洗发水）对TE和/或AGA患者的疗效和安全性。这是一项前瞻性、单臂、开放标签研究，纳入了35名女性和10名男性，中位年龄44岁，临床诊断为TE和/或AGA。他们每天使用洗发水和乳液的组合，持续90天。未发生不良事件。光镜检查显示在T90时生长期毛发的平均数量增加（P <.001）。头皮显微摄影显示在T90时总毛囊单位、毛发总数和每个毛囊单位的中位毛发数量增加。T90时毛发直径增加（P =.003），中位最大负荷和抗拉伸能力增加（P =.040）。梳理和洗涤试验表明，洗涤前（P =.005）、洗涤后（P =.01）和总的脱发数量减少（P <.001）。每天使用洗发水+乳液对减轻TE和/或AGA男性和女性的脱发是安全有效的。
