Suppr超能文献

口服富含极性脂质的小麦提取物对急性休止期脱发的恢复作用:一项随机双盲安慰剂对照研究。

Recovery Effects of Oral Supplementation with Polar Lipid-Rich Wheat Extracts on Acute Telogen Effluvium: A Randomized Double-Blind Placebo-Controlled Study.

作者信息

Nobile Vincenzo, Dudonné Stéphanie, Kern Catherine, Cestone Enza, Garcia Christine

机构信息

R&D Department, Complife Italia S.r.l., San Martino Siccomario, Italy.

Research and Innovation Department, Seppic, La Garenne Colombes, France.

出版信息

Clin Cosmet Investig Dermatol. 2025 May 20;18:1239-1251. doi: 10.2147/CCID.S521215. eCollection 2025.

Abstract

BACKGROUND

Acute telogen effluvium (aTE) is a transient condition characterized by an early entry of the hair into the telogen phase.

PURPOSE

This clinical study aimed at demonstrating the efficacy of a standardized wheat polar lipid complex both in oil (WPLC-O) and in powder (WPLC-P) form in improving hair shedding.

SUBJECTS AND METHODS

The study was carried out in 99 healthy women with aTE. Hair growth cycle related parameters (anagen/telogen hair), hair pull test, hair shaft mechanical properties (hair elongation at break) and hair growth were assessed at baseline and after 56 (D56) and/or 84 (D84) days of products use. These parameters were completed by the subject's self-assessment.

RESULTS

Telogen hair density was decreased by up to 26.9% and 24.2% while anagen density was increased by up to 10.3% and 10.8%, for WPLC-O and WPLC-P, respectively. These effects were significant compared with the placebo as early as within 56 days. These variations corresponded to an increase in the anagen/telogen ratio by up to 62.2% and 53.3% for WPLC-O and WPLC-P, respectively. Hair growth was also significantly increased in both active groups. At the end of the study the pull test was negative for aTE, exclusively in active treatment arms.

CONCLUSION

Our findings demonstrated the efficacy of WPLC in both form in reducing hair shedding and in improving hair growth in women with aTE.

摘要

背景

急性休止期脱发(aTE)是一种短暂性病症,其特征为毛发过早进入休止期。

目的

本临床研究旨在证明标准化小麦极性脂质复合物的油剂(WPLC-O)和粉剂(WPLC-P)形式在改善脱发方面的功效。

受试者与方法

该研究针对99名患有急性休止期脱发的健康女性进行。在基线以及使用产品56天(D56)和/或84天(D84)后,评估与毛发生长周期相关的参数(生长期/休止期毛发)、拔毛试验、毛干机械性能(断裂时毛发伸长率)和头发生长情况。这些参数由受试者自我评估补充完善。

结果

对于WPLC-O和WPLC-P,休止期毛发密度分别降低了26.9%和24.2%,而生长期密度分别增加了10.3%和10.8%。与安慰剂相比,这些效果早在56天内就很显著。这些变化分别对应WPLC-O和WPLC-P的生长期/休止期比率增加了62.2%和53.3%。两个活性组的头发生长也显著增加。在研究结束时,仅在活性治疗组中,aTE的拔毛试验结果为阴性。

结论

我们的研究结果证明了WPLC的两种形式在减少患有aTE的女性脱发和促进头发生长方面的功效。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验