Medical Research Unit, Spine Centre of Southern Denmark, University Hospital of Southern, Odense, Denmark.
Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Scand J Pain. 2021 Oct 19;22(3):597-613. doi: 10.1515/sjpain-2021-0090. Print 2022 Jul 26.
The aim of the current study was to examine the convergent validity of the Central Sensitization Inventory by quantifying the correlation with experimental measures of pain sensitivity and self-reported psycho-social questionnaires, in a low back pain population.
All participants were recruited from an outpatient hospital spine care clinic (Spine Centre of Southern Denmark). Participants underwent a standardized experimental pain test protocol and completed the Central Sensitization Inventory (CSI) along with additional self-reported questionnaires to assess psycho-social constructs across different domains. The association between the CSI, experimental pain measures and other self-reported psycho-social questionnaires were analyzed using correlation and contingency tests. ROC-curve analysis was used to determine sensitivity and specificity for CSI.
One hundred sixty-eight (168) participants were included. The CSI was weakly correlated with nine out of 20 variables in the experimental pain test protocol (rho range -0.37 to 0.22). The CSI was more closely correlated with psycho-social factors such as work ability, disability, and symptoms of exhaustion disorder. ROC-analysis identified an optimal cut-point of 44 on CSI (Sn=39.1% Sp=87.4%). The CSI had an area under the ROC curve of 0.656. Fisher's exact test demonstrated a statistically significant association between participants scoring ≥40 on CSI and participants categorized as sensitized by experimental pain tests (p-value=0.03).
Our findings are consistent with previous studies, indicating that the CSI is related to psycho-social constructs. However, the convergent validity with experimental pain measures is small and probably not clinically meaningful.
本研究旨在通过量化与疼痛敏感性的实验测量和自我报告的心理社会问卷的相关性，来检验中枢敏化量表的聚合效度，研究对象为腰痛人群。
所有参与者均来自丹麦南部脊柱护理诊所（南部丹麦脊柱中心）的门诊。参与者接受了标准化的实验性疼痛测试方案，并完成了中枢敏化量表（CSI）以及其他自我报告问卷，以评估不同领域的心理社会结构。使用相关性和一致性检验分析 CSI 与实验性疼痛测量值和其他自我报告的心理社会问卷之间的关联。使用 ROC 曲线分析确定 CSI 的灵敏度和特异性。
共纳入 168 名参与者。CSI 与实验性疼痛测试方案中的 20 个变量中的 9 个呈弱相关（rho 范围为-0.37 至 0.22）。CSI 与心理社会因素（如工作能力、残疾和疲惫障碍症状）的相关性更强。ROC 分析确定 CSI 的最佳截断值为 44（Sn=39.1% Sp=87.4%）。CSI 的 ROC 曲线下面积为 0.656。Fisher 精确检验表明，CSI 评分≥40 的参与者与通过实验性疼痛测试分类为敏感化的参与者之间存在统计学显著关联（p 值=0.03）。
我们的研究结果与之前的研究一致，表明 CSI 与心理社会结构相关。然而，与实验性疼痛测量的聚合效度较小，可能没有临床意义。
