血糖控制对糖尿病视网膜病变黄斑厚度的影响。

Influence of glycaemic control on macular thickness in diabetic retinopathy.

机构信息

Mechi Eye Hospital, Jhapa, Nepal.

Department of Retina, B.P Koirala Lions Center for Ophthalmic Studies (BPKLCOS), Institute of Medicine, Kathmandu, Nepal.

出版信息

Endocrinol Diabetes Metab. 2022 Jan;5(1):e00308. doi: 10.1002/edm2.308. Epub 2021 Oct 20.

DOI:10.1002/edm2.308

PMID:34668657

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8754239/

Abstract

INTRODUCTION

Diabetic macular oedema (DME) is one of the major cause of decreased visual acuity in patients with diabetic retinopathy. Poor glycaemic control is associated with increased incidence of DME.

METHODS

A total of 112 eyes of 112 patients were studied in this cross-sectional study and were classified into three groups based on HbA1c: group 1 included patients with good glycaemic control (HbA1c ≤7%), group 2 included patients with moderate glycaemic control (HbA1c between 7% and 9%) and group 3 included patients with poor glycaemic control (HbA1c ≥9%).

RESULTS

We included 112 eyes of 112 patients. The mean duration of diabetes mellitus (DM) was 11.37 years. In statistical analysis, CMT (mean 188.80 ± 27.64 μm) positively correlated with mean HbA1c level (7.95 ± 1.29%) (r = 0.238, p < .05). There was a significant difference in CMT values among the three groups of HbA1c (F (2,109) = 19.39, p < .001). Post hoc analysis showed statistical significance between HbA1c≤7% and HbA1c ≥9% group and HbA1c 7%-9% and ≥9% group. However, statistical significance was not found among HbA1c ≤7% group and HbA1c 7%-9% group. Multiple regression analyses showed a significant correlation between CMT and HbA1c after adjusting for age and duration of diabetes.

CONCLUSION

Serum HbA1c level has a significant correlation with CMT in diabetic patients.

摘要

简介

糖尿病性黄斑水肿（DME）是糖尿病视网膜病变患者视力下降的主要原因之一。血糖控制不佳与 DME 的发生率增加有关。

方法

本横断面研究共纳入 112 例 112 只眼的患者，根据糖化血红蛋白（HbA1c）将其分为 3 组：组 1 为血糖控制良好（HbA1c≤7%）的患者，组 2 为血糖控制中等（HbA1c 为 7%~9%）的患者，组 3 为血糖控制不佳（HbA1c≥9%）的患者。

结果

我们纳入了 112 例 112 只眼的患者。糖尿病病程的平均时间为 11.37 年。在统计学分析中，CMT（平均 188.80±27.64μm）与平均 HbA1c 水平（7.95±1.29%）呈正相关（r=0.238，p<.05）。3 组 HbA1c 的 CMT 值存在显著差异（F（2,109）=19.39，p<.001）。事后分析显示，HbA1c≤7%和 HbA1c≥9%组与 HbA1c 7%-9%和≥9%组之间存在统计学意义。然而，HbA1c≤7%组与 HbA1c 7%-9%组之间未发现统计学意义。多元回归分析显示，在调整年龄和糖尿病病程后，CMT 与 HbA1c 呈显著相关。