血糖控制及变异性在糖尿病视网膜病变中的作用
The Role of Glycemic Control and Variability in Diabetic Retinopathy.
作者信息
Chatziralli Irini P
机构信息
2nd Department of Ophthalmology, University of Athens, Athens, Greece.
出版信息
Diabetes Ther. 2018 Feb;9(1):431-434. doi: 10.1007/s13300-017-0345-5. Epub 2017 Nov 30.
Abstract
Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM) and is considered the leading cause of visual impairment in working-aged adults worldwide. The duration of DM and hyperglycemia have been associated with DR, although the exact role in the pathogenesis of DR and diabetic macular edema remains controversial. As a result, a reasonable question arising is whether control of blood glucose levels may alter the course of DR. Studies have shown that glycemic control remains an important factor for the presence and progression of DR. HbA1c seems to be an indicator which cannot demonstrate exactly the degree of glycemic control, while sudden variations of blood glucose may play an important role in DR; therefore, glycemic variability may be useful to predict DM complications, such as DR.
摘要
糖尿病视网膜病变（DR）是糖尿病（DM）常见的微血管并发症，被认为是全球工作年龄成年人视力损害的主要原因。糖尿病病程和高血糖与糖尿病视网膜病变有关，尽管其在糖尿病视网膜病变和糖尿病性黄斑水肿发病机制中的确切作用仍存在争议。因此，出现的一个合理问题是血糖水平的控制是否会改变糖尿病视网膜病变的病程。研究表明，血糖控制仍然是糖尿病视网膜病变发生和进展的一个重要因素。糖化血红蛋白（HbA1c）似乎是一个不能准确显示血糖控制程度的指标，而血糖的突然变化可能在糖尿病视网膜病变中起重要作用；因此，血糖变异性可能有助于预测糖尿病并发症，如糖尿病视网膜病变。
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