Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Haidian District, Beijing, 100084, China.
Mol Biol Rep. 2022 Jan;49(1):675-685. doi: 10.1007/s11033-021-06836-6. Epub 2021 Oct 20.
The serum and glucocorticoid-induced kinase-1 (SGK1) belonging to the AGC protein kinase family phosphorylates serine and threonine residues of target proteins. It regulates numerous ion channels and transporters and promotes survival under cellular stress. Unique to SGK1 is a tight control at transcriptional and post-transcriptional levels. SGK1 regulates multiple signal transduction pathways related to tumor development. Several studies have reported that SGK1 is upregulated in different types of human malignancies and induces resistance against inhibitors, drugs, and targeted therapies.
This review highlights the cellular functions of SGK1, its crucial role in cancer development, and clinical insights for SGK1 targeted therapies. Furthermore, the role of SGK1-mediated autophagy as a potential therapeutic target for cancer has been discussed.
属于 AGC 蛋白激酶家族的血清和糖皮质激素诱导激酶 1（SGK1）磷酸化靶蛋白的丝氨酸和苏氨酸残基。它调节众多离子通道和转运蛋白，并在细胞应激下促进存活。SGK1 的独特之处在于在转录和转录后水平的严格控制。SGK1 调节与肿瘤发展相关的多种信号转导途径。多项研究报道，SGK1 在不同类型的人类恶性肿瘤中上调，并对抑制剂、药物和靶向治疗产生耐药性。
本文重点介绍了 SGK1 的细胞功能、在癌症发展中的关键作用以及针对 SGK1 的靶向治疗的临床见解。此外，还讨论了 SGK1 介导的自噬作为癌症潜在治疗靶点的作用。
