Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmacol Res. 2024 Oct;208:107369. doi: 10.1016/j.phrs.2024.107369. Epub 2024 Aug 28.
Cardiac diseases encompass a wide range of conditions that affect the structure and function of the heart. These conditions are a leading cause of morbidity and mortality worldwide. The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a serine/threonine kinase that plays a significant role in various cellular processes, including cell survival and stress response. Alterations in SGK1 activity can have significant impacts on health and disease. Multiple research findings have indicated that SGK1 is associated with heart disease due to its involvement in cardiac hypertrophy and fibrosis. This article reviews different signaling pathways associated with SGK1 activity in various heart conditions, including the SGK1/NF-κB and PI3K/SGK1 pathways.
心脏病包括一系列影响心脏结构和功能的疾病。这些疾病是全球发病率和死亡率的主要原因。血清和糖皮质激素诱导的激酶 1（SGK1）是一种丝氨酸/苏氨酸激酶，在多种细胞过程中发挥重要作用，包括细胞存活和应激反应。SGK1 活性的改变对健康和疾病有重大影响。多项研究发现，SGK1 与心脏病有关，因为它参与了心肌肥大和纤维化。本文综述了不同信号通路与各种心脏疾病中 SGK1 活性的关系，包括 SGK1/NF-κB 和 PI3K/SGK1 通路。
