癌症与微环境可塑性：转移中的双刃剑。
Cancer and Microenvironment Plasticity: Double-Edged Swords in Metastasis.
机构信息
CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
出版信息
Trends Pharmacol Sci. 2019 Jun;40(6):419-429. doi: 10.1016/j.tips.2019.04.005. Epub 2019 May 8.
Cancer initiates at one site (primary tumor) and, in most cases, spreads to other distant organs (metastasis). During the multistep process of metastasis, primary tumor cells acquire cellular and phenotypic plasticity to survive and thrive in different environments. Moreover, cancer cells also utilize and educate microenvironmental components by reshaping them into accomplices of metastasis. Recent studies have identified a plethora of new molecular and cellular modulators of metastasis that have dynamic or even opposite roles, dominating the phenotypic plasticity of both tumoral and microenvironmental components. In this review we discuss their bipotential functions and the possible underpinning mechanisms, as well as their implications for targeted cancer therapy.
癌症起始于一个部位（原发性肿瘤），并且在大多数情况下，会扩散到其他远处器官（转移）。在转移的多步骤过程中，原发性肿瘤细胞获得细胞和表型可塑性，以在不同的环境中存活和生长。此外，癌细胞还通过重塑它们成为转移的帮凶来利用和教育微环境成分。最近的研究已经确定了大量新的分子和细胞转移调节剂，它们具有动态的甚至相反的作用，主导着肿瘤和微环境成分的表型可塑性。在这篇综述中，我们讨论了它们的双重功能和可能的基础机制，以及它们对靶向癌症治疗的意义。
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