Department of Oncology & Hematology, Azienda Ospedaliero-Universitaria of Modena, Modena, 41124, Italy.
Department of Radiology, University of Modena & Reggio Emilia, Azienda Ospedaliero-Universitaria of Modena, Modena, 41124, Italy.
Immunotherapy. 2021 Dec;13(18):1501-1519. doi: 10.2217/imt-2021-0038. Epub 2021 Oct 21.
Immunotherapy changed the landscape of non-small-cell lung cancer (NSCLC). Efforts were made to implement its action. This study aims to describe body composition, nutritional and inflammatory status in NSCLC patients treated by first-line immunotherapy, their correlation, variation and impact. We retrospectively analyzed 44 consecutive patients who received pembrolizumab treatment. During the therapy, inflammation and visceral fat increased, whereas muscle and subcutaneous fat decreased. Parameters related to inflammation had an interesting prognostic impact. High numbers of white blood cells remained significantly correlated with a high risk of death in multivariate model. For the best treatment choice, a combination of clinical and biological factors will be most likely be necessary. Prospective and larger studies with a multidimensional approach are needed.
免疫疗法改变了非小细胞肺癌（NSCLC）的治疗格局。人们努力实施其作用。本研究旨在描述一线免疫治疗的 NSCLC 患者的身体成分、营养和炎症状况，及其相关性、变化和影响。我们回顾性分析了 44 例连续接受派姆单抗治疗的患者。在治疗过程中，炎症和内脏脂肪增加，而肌肉和皮下脂肪减少。与炎症相关的参数具有有趣的预后影响。白细胞数量高在多变量模型中仍与死亡风险高显著相关。为了做出最佳治疗选择，很可能需要将临床和生物学因素结合起来。需要进行前瞻性和更大规模的多维研究。
