Owlia Fatemeh, Mahmoudzade Nazanin, Modaresi Jalil, Zarchi Marzieh Abutorabi
Department of Oral and Maxillofacial Medicine, Social Determinants of Oral Health Research Center, School of Dentistry, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Islamic Republic of Iran.
School of Dentistry, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Islamic Republic of Iran.
BMC Neurol. 2021 Oct 20;21(1):403. doi: 10.1186/s12883-021-02416-0.
The importance of evaluating the pulpal threshold to electrical stimulation, as a side effect of probable neuropathy in Multiple Sclerosis (MS) patients is a novel issue. This study aimed to investigate electrical pulp test thresholds in MS patients without a history of trigeminal neuralgia compared to healthy individuals.
Sixty-nine maxillary central incisors, belonging to 34 relapsing-remitting MS patients, and 35 healthy individuals were included in this survey. The MS patients matched for intended variables, were 22-50 years old, had a more than 1-year history of MS, no history of trigeminal neuralgia and/or other neuropathy. The electric pulp sensibility test was performed on all samples. Electric pulp testing (EPT) results were recorded based on the pulp testers grade that evoked a response. Data were analyzed with paired T-test, Mann-Whitney test, and Spearman correlation (P < 0.05).
According to the results of this study, the mean values of response to EPT were 1.2 ± 0.5 and 1.8 ± 0.5 in MS patients and healthy individuals, respectively. The pulpal response to EPT between the two groups was significantly different (P < 0.0001).
MS patients showed a significantly reduced response to the electric pulp test in their maxillary central incisors in comparison to matched healthy persons.
评估牙髓对电刺激的阈值作为多发性硬化症（MS）患者可能出现的神经病变的副作用，是一个新问题。本研究旨在调查无三叉神经痛病史的MS患者与健康个体相比的牙髓电测试阈值。
本调查纳入了属于34例复发缓解型MS患者的69颗上颌中切牙和35名健康个体。匹配了预期变量的MS患者年龄在22至50岁之间，有超过1年的MS病史，无三叉神经痛和/或其他神经病变病史。对所有样本进行牙髓电敏感性测试。根据引起反应的牙髓测试仪等级记录牙髓电测试（EPT）结果。数据采用配对T检验、曼-惠特尼检验和斯皮尔曼相关性分析（P < 0.05）。
根据本研究结果，MS患者和健康个体对EPT的反应平均值分别为1.2±0.5和1.8±0.5。两组之间对EPT的牙髓反应有显著差异（P < 0.0001）。
与匹配的健康人相比，MS患者上颌中切牙对牙髓电测试的反应明显降低。
