Ito N, Fukushima S, Tamano S, Hirose M, Hagiwara A
J Natl Cancer Inst. 1986 Dec;77(6):1261-5.
Groups of 50 6-week-old male F344 rats were given a powdered diet containing 0, 0.125, 0.25, 0.5, 1, or 2% butylated hydroxyanisole [(BHA) CAS: 25013-16-5] for 104 weeks. The highest dose--2% BHA--induced significant increase in the incidence of squamous cell carcinoma of the forestomach. Papillomas of the forestomach developed in 20 and 100% of the rats given diets containing 1 and 2% BHA, respectively. The incidence of epithelial hyperplasia of the forestomach increased with the increased BHA doses, to 100% incidence at the highest dose. Thus the incidences of proliferative and neoplastic lesions of the forestomach were dose dependent.
将50只6周龄雄性F344大鼠分为几组，分别给予含0%、0.125%、0.25%、0.5%、1%或2%丁基羟基茴香醚[(BHA)，化学物质登记号：25013-16-5]的粉状饲料，持续104周。最高剂量——2%BHA——导致前胃鳞状细胞癌的发病率显著增加。分别给予含1%和2%BHA饲料的大鼠中，前胃乳头状瘤的发生率分别为20%和100%。前胃上皮增生的发生率随BHA剂量的增加而增加，在最高剂量时发生率达到100%。因此，前胃增生性和肿瘤性病变的发生率呈剂量依赖性。
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