给予胡薄荷酮的F344/DuCrj大鼠和B6C3F1小鼠前胃肿瘤的诱导
Forestomach neoplasm induction in F344/DuCrj rats and B6C3F1 mice exposed to sesamol.
作者信息
Tamano S, Hirose M, Tanaka H, Asakawa E, Ogawa K, Ito N
机构信息
First Department of Pathology, Nagoya City University Medical School.
出版信息
Jpn J Cancer Res. 1992 Dec;83(12):1279-85. doi: 10.1111/j.1349-7006.1992.tb02759.x.
Abstract
Sesamol was administered at a dietary level of 2% to groups of 30 male and female F344/DuCrj rats and B6C3F1 mice for 104 and 96 weeks, respectively. Squamous cell carcinomas in the forestomach were induced in nine of 29 (31%) effective male rats, three of 30 (10%) female rats, eleven of 29 (38%) male mice and five of 30 (17%) female mice treated with sesamol. Papillomas developed in ten of 29 (34%) male rats and fourteen of 30 (47%) female rats, but not in any of the mice. Hyperplasias developed in almost all rats and mice of both sexes. Significant differences from control values were found for all three lesions in rats and for carcinoma and hyperplasia categories in mice. The incidences of other tumors in the 2% sesamol group were comparable with control values. In conclusion, sesamol induces squamous cell carcinomas in the forestomach of rats and mice, males being more susceptible than females.
摘要
将芝麻酚以2%的膳食水平分别给予30只雄性和雌性F344/DuCrj大鼠及B6C3F1小鼠，持续104周和96周。在接受芝麻酚处理的29只雄性大鼠中有9只（31%）、30只雌性大鼠中有3只（10%）、29只雄性小鼠中有11只（38%）以及30只雌性小鼠中有5只（17%）诱发了前胃鳞状细胞癌。乳头状瘤在29只雄性大鼠中有10只（34%）、30只雌性大鼠中有14只（47%）出现，但在任何小鼠中均未出现。几乎所有雌雄大鼠和小鼠均出现增生。在大鼠中，这三种病变以及在小鼠中癌和增生类别与对照值均存在显著差异。2%芝麻酚组中其他肿瘤的发生率与对照值相当。总之，芝麻酚可诱发大鼠和小鼠前胃鳞状细胞癌，雄性比雌性更易受影响。
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