Donti E, Tabilio A, Rosetti A, Carotti A, Bordoni S, Falzetti F, Venti Donti G
Leuk Res. 1986;10(12):1487-91. doi: 10.1016/0145-2126(86)90018-4.
A chronic myeloid leukemia (CML) patient who had presented a t(2;9;22) translocation during the chronic phase developed an unusual t(4;21) (p16;q22) translocation during the M2 type FAB classification blastic crisis. The role of these two recombinant chromosomes in the genesis of the terminal phase is discussed, particularly as the breakpoint on chromosome 21 near to the ets-2 oncogene locus, seems to be the same as that described in the t(8;21) (q22;q22) translocation specific of type M2 AML.
一名慢性粒细胞白血病（CML）患者在慢性期出现了t(2;9;22)易位，在M2型FAB分类的急变期发展为异常的t(4;21)(p16;q22)易位。讨论了这两条重组染色体在终末期发生过程中的作用，特别是21号染色体上靠近ets-2癌基因位点的断裂点，似乎与M2型急性髓系白血病（AML）特有的t(8;21)(q22;q22)易位中描述的断裂点相同。
