Grossman A, Rosenberg R N, Warmoth L
Neurology. 1987 Jan;37(1):106-11. doi: 10.1212/wnl.37.1.106.
The activities of brain glutamate dehydrogenase and malate dehydrogenase were not statistically different in samples from patients with autosomal dominant olivopontocerebellar atrophy or Joseph disease compared with control subject samples. These two enzymes are thus not involved in the pathogenesis of these two separate dominantly inherited diseases.
与对照样本相比,常染色体显性遗传性橄榄体脑桥小脑萎缩症(OPCA)患者或约瑟夫病患者样本中的脑谷氨酸脱氢酶和苹果酸脱氢酶活性无统计学差异。因此,这两种酶不参与这两种独立的显性遗传性疾病的发病机制。