Duvoisin R C, Nicklas W J, Ritchie V, Sage J, Chokroverty S
Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903.
J Neurol Neurosurg Psychiatry. 1988 Dec;51(12):1508-11. doi: 10.1136/jnnp.51.12.1508.
Leucocyte glutamate dehydrogenase (GDH) activity was measured in 26 normal control subjects, 20 patients with multiple system atrophy presenting features of either olivopontocerebellar atrophy or striatonigral degeneration and in a heterogenous group of 15 patients with spinocerebellar degenerations. A broad range of GDH activity was found in all three groups. Low activity failed to correlate with a specific clinical entity. Patients followed to post-mortem examination to date have demonstrated histological features of at least three distinct morbid entities. It is concluded, contrary to earlier reports including the authors', that low leukocyte GDH activity does not identify a particular type of multiple system atrophy.
在26名正常对照受试者、20名表现为橄榄脑桥小脑萎缩或纹状体黑质变性特征的多系统萎缩患者以及15名患有脊髓小脑变性的异质性患者组中测量了白细胞谷氨酸脱氢酶（GDH）活性。在所有三组中均发现了广泛的GDH活性范围。低活性与特定临床实体无关。迄今为止接受尸检的患者已表现出至少三种不同病态实体的组织学特征。得出的结论是，与包括作者在内的早期报告相反，低白细胞GDH活性并不能识别特定类型的多系统萎缩。
