Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, China.
West China School of Medicine, Sichuan University, Chengdu, China.
Crit Rev Food Sci Nutr. 2023;63(19):3771-3787. doi: 10.1080/10408398.2021.1993781. Epub 2021 Oct 21.
Folic acid, a water-soluble vitamin B nutrient, plays an important role not only in maintaining a healthy pregnancy but also in offspring brain development and function, however, it remains unclear whether maternal folic acid (FA) supplementation associated with the risk of different postnatal neurodevelopmental outcomes. Here, we performed a systematic review and meta-analysis on the impact of maternal FA supplementation on a wide range of postnatal neurodevelopmental outcomes which include intellectual development, risk of autistic traits, ADHD, behavior, language, and psychomotor problems, using studies extracted from the following databases, including MEDLINE, Web of Science, Cochrane Library, Scopus, EMBASE, and PsychInfo. Thirty-two cohort studies and seven case-control studies were included in this meta-analysis. In the present study, we found that prenatal FA supplementation had a positive impact on offspring's neurodevelopmental outcomes, including improved intellectual development and reduced risk of autism traits, ADHD, behavioral, and language problems. We also found that FA over-supplementation was not associated with an improvement in offspring's brain development, and may have a negative impact on offspring's neurodevelopmental outcomes. This study proved the first panoramic review on the relationship of FA supplementation with offspring's neurodevelopment. Further studies focusing on different dosages and periods of FA supplementation are needed.Supplemental data for this article is available online at https://doi.org/10.1080/10408398.2021.1993781 .
叶酸是一种水溶性维生素 B 营养物质，不仅在维持健康妊娠中起着重要作用，而且在后代大脑发育和功能中也起着重要作用，然而，目前尚不清楚母体叶酸（FA）补充是否与不同的产后神经发育结局的风险相关。在这里，我们对母体 FA 补充对广泛的产后神经发育结局（包括智力发育、自闭症特征、ADHD、行为、语言和运动问题的风险）的影响进行了系统回顾和荟萃分析，使用了从以下数据库中提取的研究，包括 MEDLINE、Web of Science、Cochrane 图书馆、Scopus、EMBASE 和 PsychInfo。本荟萃分析纳入了 32 项队列研究和 7 项病例对照研究。在本研究中，我们发现产前 FA 补充对后代的神经发育结局有积极影响，包括改善智力发育和降低自闭症特征、ADHD、行为和语言问题的风险。我们还发现 FA 过度补充与改善后代大脑发育无关，并且可能对后代的神经发育结局产生负面影响。这项研究证明了 FA 补充与后代神经发育关系的首次全景综述。需要进一步研究不同剂量和补充 FA 时间的研究。本文的补充数据可在 https://doi.org/10.1080/10408398.2021.1993781 在线获取。
