Department of Neurology and Psychiatry, Faculty of Medicine, Assiut University, Assiut, Egypt; Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.
Department of Neurology and Psychiatry, Faculty of Medicine, Assiut University, Assiut, Egypt.
Psychiatry Res. 2021 Nov;305:114243. doi: 10.1016/j.psychres.2021.114243. Epub 2021 Oct 12.
The long-term impact of the COVID-19 infection on mental health in people and its relation to the severity is unclear. We aimed to study the long-term effect of post-COVID-19 disease on sleep and mental health and to detect possible relationship between severity of COVID-19 at onset and sleep and mental illness. We enrolled 182 participants 6 months post COVID-19 infection and grouped into non-severe(101),severe(60) and critical(20) according to according to WHO guidance. All participants were assessed using Pittsburgh Sleep Quality Index ", Post traumatic stress disorder (PTSD) Checklist for DSM-5, and Symptom Checklist90 test. Only 8.8% had no psychiatric symptoms while 91.2% had psychiatric symptoms as follow (poor sleep (64.8%), PTSD (28.6%), somatization (41.8%), obsessive-compulsive (OCD) (19.8%), depression (11.5%), anxiety (28%), phobic-anxiety (24.2%), psychoticism (17.6%)). Diabetes, oxygen support or mechanically ventilated were a risk for sleep impairment, while high Neutrophil/lymphocyte ratio(NLR) was the only risk factor for PTSD. Other psychiatric illnesses had several risk factors: being female, diabetes, oxygen support or mechanically ventilated. Abnormal sleep, somatization and anxiety are the most common mental illnesses in Post-Covid19. The critical group is common associated with PTSD, anxiety, and psychosis. Being female, diabetic, having oxygen support or mechanically ventilated, and high NLR level are more vulnerable for mental illness in post COVID19.
新冠感染对人类心理健康的长期影响及其与严重程度的关系尚不清楚。我们旨在研究新冠后疾病对睡眠和心理健康的长期影响,并检测新冠发病严重程度与睡眠和精神疾病之间的可能关系。我们招募了 182 名新冠感染 6 个月后的参与者,并根据世界卫生组织的指导将其分为非重症(101 名)、重症(60 名)和危重症(20 名)。所有参与者均使用匹兹堡睡眠质量指数、创伤后应激障碍(PTSD)检查表 5 型和症状检查表 90 进行评估。只有 8.8%的患者没有精神科症状,而 91.2%的患者有精神科症状,如下所示(睡眠不佳(64.8%)、创伤后应激障碍(28.6%)、躯体化(41.8%)、强迫观念与行为(19.8%)、抑郁(11.5%)、焦虑(28%)、恐怖性焦虑障碍(24.2%)、精神病性障碍(17.6%))。糖尿病、氧疗或机械通气是睡眠障碍的危险因素,而高中性粒细胞/淋巴细胞比值(NLR)是 PTSD 的唯一危险因素。其他精神疾病有几个危险因素:女性、糖尿病、氧疗或机械通气。异常睡眠、躯体化和焦虑是新冠后最常见的精神疾病。危重症组常见 PTSD、焦虑和精神病。女性、糖尿病、氧疗或机械通气以及高 NLR 水平的患者在新冠后更容易患精神疾病。