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一项关于新冠病毒病从感染到9个月随访期间对精神症状和睡眠问题影响的前瞻性研究。

A prospective study of the effect of COVID-19 on psychiatric symptoms and sleep problems from infection to 9-month follow-up.

作者信息

El-Morshedy Reham M, El-Kholy Maha M, Khedr Eman M, Ahmed Gellan K, Yassin Esraa, Mohamed Marwan N

机构信息

Department of Chest Diseases and Tuberculosis, Faculty of Medicine, Assiut University, Asyût, Egypt.

Department of Neurology and Psychiatry, Faculty of Medicine, Assiut University, Asyût, Egypt.

出版信息

Eur Arch Psychiatry Clin Neurosci. 2025 Feb;275(1):99-108. doi: 10.1007/s00406-023-01755-y. Epub 2024 Jan 28.

Abstract

Diverse psychological consequences of the COVID-19 pandemic have been reported for 6 months after infection. We conducted a prospective study to evaluate the psychological impact of COVID-19 infection in newly diagnosed cases that were followed up at 1, 6, and 9 months after infection. 137 people were recruited and divided into four groups based on the COVID-19 Treatment Guidelines. They were evaluated using the Pittsburgh Sleep Quality Index (PSQI), Post-traumatic stress disorder Checklist for DSM-5 (PCL-5), and Symptom Checklist 90 (SCL-90). We found that 9 months after infection, patients continued to report poor sleep (74.5%), PTSD (78.3%), somatization (17%), anxiety (17%), aggression (5.7%), phobic anxiety (4.7%), psychoticism (1.9%), paranoid (3.8%), and obsessive-compulsive (9.4%) symptoms, as well as depression and interpersonal sensitivity. The most significant risk factors for psychiatric complications were older age, level of education, smoking, hospitalization duration, hypertension, and critical severity. The negative mental health effects of COVID-19 persist after hospital discharge, and many patients continue to experience moderate-to-severe issues that may endure for 9 months. Notably, there was a progressive improvement in these symptoms over that time.

摘要

据报道,新冠疫情感染6个月后会产生多种心理后果。我们开展了一项前瞻性研究,以评估新冠病毒感染对新确诊病例的心理影响,这些病例在感染后的1个月、6个月和9个月进行了随访。招募了137人,并根据《新冠病毒治疗指南》将他们分为四组。使用匹兹堡睡眠质量指数(PSQI)、《精神疾病诊断与统计手册》第5版创伤后应激障碍检查表(PCL-5)和症状自评量表90(SCL-90)对他们进行评估。我们发现,感染9个月后,患者仍报告存在睡眠不佳(74.5%)、创伤后应激障碍(78.3%)、躯体化(17%)、焦虑(17%)、攻击性(5.7%)、恐惧焦虑(4.7%)、精神质(1.9%)、偏执(3.8%)和强迫(9.4%)症状,以及抑郁和人际敏感问题。精神并发症最显著的风险因素是年龄较大、教育程度、吸烟、住院时间、高血压和病情严重程度。新冠病毒感染对心理健康的负面影响在出院后依然存在,许多患者仍经历中度至重度问题,这些问题可能会持续9个月。值得注意的是,在这段时间里这些症状有逐渐改善的趋势。

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