代谢和心血管疾病对 COVID-19 死亡率的影响：系统评价和荟萃分析。
Impact of metabolic and cardiovascular disease on COVID-19 mortality: A systematic review and meta-analysis.
机构信息
Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, Delhi- 110029, India.
Department of Biostatistics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, Delhi- 110029, India.
出版信息
Diabetes Metab Syndr. 2021 Nov-Dec;15(6):102308. doi: 10.1016/j.dsx.2021.102308. Epub 2021 Oct 6.
BACKGROUND AND AIMS
This meta-analysis aims to highlight the impact of cardio-metabolic comorbidities on COVID-19 severity and mortality.
METHODS
A thorough search on major online databases was done for studies describing the clinical outcomes of COVID-19 patients. We used random-effects model to compute pooled estimates for critical or fatal disease.
RESULTS
A total of 20,475 patients from 33 eligible studies were included. Maximum risk of development of critical or fatal COVID-19 disease was seen in patients with underlying cardiovascular disease [OR: 3.44, 95% CI: 2.65-4.48] followed by chronic lung disease, hypertension and diabetes mellitus. Of the total cases, 64% had one of the four comorbidities with the most prevalent being hypertension with a pooled prevalence of 27%.
CONCLUSIONS
Presence of comorbidities like cardiovascular disease, chronic lung disease, hypertension and diabetes mellitus led to a higher risk of development of critical or fatal COVID-19 disease, with maximum risk seen with underlying cardiovascular disease.
背景和目的
本荟萃分析旨在强调心脏代谢合并症对 COVID-19 严重程度和死亡率的影响。
方法
对主要在线数据库进行了全面检索，以查找描述 COVID-19 患者临床结局的研究。我们使用随机效应模型计算重症或致死性疾病的汇总估计值。
结果
共有来自 33 项合格研究的 20475 名患者纳入本研究。患有基础心血管疾病的患者发生重症或致死性 COVID-19 疾病的风险最高[比值比：3.44，95%置信区间：2.65-4.48]，其次是慢性肺部疾病、高血压和糖尿病。在所有病例中，有 64%的患者合并有四种合并症中的一种，其中最常见的是高血压，其合并患病率为 27%。
结论
存在心血管疾病、慢性肺部疾病、高血压和糖尿病等合并症会增加发生重症或致死性 COVID-19 疾病的风险，其中基础心血管疾病的风险最高。
Zotero 插件