Cangemi Roberto, Di Franco Manuela, Angeloni Antonio, Zicari Alessandra, Cardinale Vincenzo, Visentini Marcella, Antonelli Guido, Napoli Anna, Anastasi Emanuela, Romiti Giulio Francesco, d'Alba Fabrizio, Alvaro Domenico, Polimeni Antonella, Basili Stefania
Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Roma, Italy.
Department of Internal Clinical, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, 00185 Roma, Italy.
J Pers Med. 2022 Jun 18;12(6):994. doi: 10.3390/jpm12060994.
Vaccine-induced immunity is a key strategy in the long-term control of the COVID-19 pandemic. The aim of our study was to explore the relationship between mRNA vaccine-induced antibodies and gender-sensitive variables among healthcare workers. Two thousand-sixty-five volunteers who received the BNT162b2 vaccine were enrolled in the study and followed up. Demographic, clinical, and social variables (educational level, marital status, occupation, childcare) were evaluated through a self-administered questionnaire. Anti-Spike (S) IgG were measured at 1 month (T1) and at 5 months (T2) after the second vaccine dose. At T1, median anti-S IgG values were 693 [394−>800] AU/mL (1 AU = 2.6 BAU). Values > 800 AU/mL (2080 BAU/mL) were directly associated with a previous COVID-19 (p < 0.001) infection and inversely with age (p < 0.001), smoking habit (p < 0.001), and autoimmune diseases (p < 0.001). At T2, a significant decreasing in anti-S IgG values was observed (187 [81−262] AU/mL), with a median decrease of 72 [60−82]%. On multivariate data analysis, a reduction of more than 82% was directly associated with male sex (p < 0.021), age (p < 0.001), smoking (p = 0.038), hypertension (p = 0.042), and, inversely, with previous COVID-19 infection (p < 0.001) and being “cohabiting” (p = 0.005). Our findings suggest that demographic, clinical, and social variables play a role in anti-S IgG values decreasing in long-term follow up and should be considered to find personalized vaccine schedules.
疫苗诱导的免疫是长期控制新冠疫情的关键策略。我们研究的目的是探索医护人员中mRNA疫苗诱导的抗体与性别敏感变量之间的关系。2065名接种BNT162b2疫苗的志愿者参与了本研究并接受随访。通过自填问卷评估人口统计学、临床和社会变量（教育程度、婚姻状况、职业、子女照料情况）。在第二次接种疫苗后的1个月（T1）和5个月（T2）测量抗刺突（S）IgG。在T1时，抗S IgG值中位数为693[394−>800]AU/mL（1 AU = 2.6 BAU）。值>800 AU/mL（2080 BAU/mL）与既往新冠病毒感染直接相关（p<0.001），与年龄、吸烟习惯、自身免疫性疾病呈负相关（p<0.001）。在T2时，观察到抗S IgG值显著下降（187[81−262]AU/mL），中位数下降72[60−82]%。多变量数据分析显示，下降超过82%与男性（p<0.021）、年龄（p<0.001）、吸烟（p = 0.038）、高血压（p = 0.042）直接相关，与既往新冠病毒感染（p<0.001）和“同居”（p = 0.005）呈负相关。我们的研究结果表明，人口统计学、临床和社会变量在长期随访中抗S IgG值下降中起作用，在制定个性化疫苗接种计划时应予以考虑。
