Department of Ophthalmology, Korea University College of Medicine, 73 Goryeodae-ro, Sungbuk-ku, Seoul, South Korea, 02841.
Graefes Arch Clin Exp Ophthalmol. 2022 Mar;260(3):759-769. doi: 10.1007/s00417-021-05469-6. Epub 2021 Oct 21.
To investigate hyperreflective choroidal foci (HCF) using en face swept-source optical coherence tomography (SS-OCT) and determine the factors that contribute to the distribution of HCF in normal eyes.
In this retrospective study, we included healthy eyes with a normal fundus. HCF were defined as hyperreflective spots on en face SS-OCT images. The number, mean area, total area, and circularity of the HCF were compared with various choroid measurements obtained using SS-OCT, SS-OCT angiography, and fundus photography.
We investigated 51 eyes from 51 patients. The mean patient age was 56.0 ± 14.7 years, and 32 (62.7%) were female. The number and total area of HCF did not differ between the female and male patients and the right and left eyes. The number of HCF was correlated with the stromal area of the choroid (r = 0.291, P = 0.040) and subfoveal choroidal vascularity index (r = - 0.364, P = 0.009). The total area of HCF was correlated with the stromal area of the choroid (r = 0.283, P = 0.045). However, the number and total area of HCF were not correlated with age, degree of macular tessellation, subfoveal choroidal thickness, and choriocapillaris vascular density and flow void area.
HCF were observed in normal eyes, and their distribution was associated with the underlying stromal component of the choroid. The results of this study can be used as a reference for determining abnormal hyperreflective foci in the choroid of the eyes with various diseases.
利用共焦激光扫描检眼镜（SS-OCT）对高反射脉络膜病灶（HCF）进行研究，并确定导致正常眼中 HCF 分布的因素。
在这项回顾性研究中，我们纳入了眼底正常的健康眼。HCF 定义为 SS-OCT 图像上的高反射斑点。比较了 HCF 的数量、平均面积、总面积和圆度与 SS-OCT、SS-OCT 血管造影和眼底照相获得的各种脉络膜测量值。
我们研究了 51 名患者的 51 只眼。患者的平均年龄为 56.0±14.7 岁，其中 32 名（62.7%）为女性。女性和男性患者以及右眼和左眼的 HCF 数量和总面积无差异。HCF 的数量与脉络膜基质面积呈正相关（r=0.291，P=0.040），与黄斑区血管密度呈负相关（r=-0.364，P=0.009）。HCF 的总面积与脉络膜基质面积呈正相关（r=0.283，P=0.045）。然而，HCF 的数量和总面积与年龄、黄斑区镶嵌程度、脉络膜下厚度以及脉络膜毛细血管密度和血流空洞面积均无相关性。
在正常眼中观察到 HCF，其分布与脉络膜的基质成分有关。本研究的结果可作为确定各种疾病眼脉络膜异常高反射病灶的参考。
