Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.
Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Sci Rep. 2023 Sep 22;13(1):15847. doi: 10.1038/s41598-023-41691-4.
This study aimed to evaluate perivascular reflectivity in patients with branched retinal vascular obstruction (BRVO) using en-face optical coherence tomography (OCT). The study retrospectively analyzed 45 patients with recurrent BRVO, 30 with indolent BRVO, and 45 age- and sex-matched controls. Using a 3.0 × 3.0-mm deep capillary plexus slab on macular scans, OCT angiography (OCTA) and structural en-face OCT scans were divided into four quadrants. Obstructive quadrants of OCTA scans were binarized using a threshold value of mean + 2 standard deviation. The selected area of high signal strength (HSS) was applied to the structural en-face OCT scans, and the corrected mean perivascular reflectivity was calculated as the mean reflectivity on the HSS area/overall en-face OCT mean reflectivity. The same procedure was performed in the quadrants of the matched controls. Regression analysis was conducted on several factors possibly associated with corrected perivascular reflectivity. The perivascular reflectivity in the obstructive BRVO quadrant was significantly higher than in the indolent BRVO and control quadrants (P = 0.009, P = 0.003). Both univariate and multivariate regression analyses showed a significant correlation between the average number of intravitreal injections (anti-vascular endothelial growth factor or dexamethasone implant) per year and refractive errors and image binarization threshold and perivascular reflectivity (P = 0.011, 0.013, < 0.001/univariate; 0.007, 0.041, 0.005/multivariate, respectively). En-face OCT scans of the deep capillary plexus slab revealed higher perivascular reflectivity in recurrent BRVO eyes than in indolent BRVO and control eyes. The results also indicate a remarkable correlation between perivascular reflectivity and the average number of intravitreal injections, suggesting a link to recurrence rates.
本研究旨在利用共焦光学相干断层扫描（OCT）评估分支状视网膜血管阻塞（BRVO）患者的血管周围反射率。该研究回顾性分析了 45 例复发性 BRVO 患者、30 例惰性 BRVO 患者和 45 例年龄和性别匹配的对照组。在黄斑扫描的 3.0×3.0mm 深部毛细血管丛板上，OCT 血管造影（OCTA）和结构共焦 OCT 扫描分为四个象限。使用平均+2 个标准差的阈值对 OCTA 扫描的阻塞象限进行二值化。将高信号强度（HSS）的选定区域应用于结构共焦 OCT 扫描，并将校正后的血管周围反射率计算为 HSS 区域的平均反射率/整个共焦 OCT 平均反射率。在匹配对照组的象限中进行了相同的处理。对可能与校正后的血管周围反射率相关的几个因素进行回归分析。阻塞性 BRVO 象限的血管周围反射率明显高于惰性 BRVO 和对照组（P=0.009，P=0.003）。单变量和多变量回归分析均显示，每年玻璃体内注射（抗血管内皮生长因子或地塞米松植入物）的平均次数与屈光不正和图像二值化阈值与血管周围反射率之间存在显著相关性（P=0.011，0.013，<0.001/单变量；0.007，0.041，0.005/多变量）。深部毛细血管丛板的共焦 OCT 扫描显示，复发性 BRVO 眼的血管周围反射率高于惰性 BRVO 和对照组。结果还表明血管周围反射率与玻璃体内注射次数的平均数量之间存在显著相关性，提示与复发率有关。
