Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, People's Republic of China.
Department of Ultrasound, The First Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China.
Drug Des Devel Ther. 2021 Oct 7;15:4243-4255. doi: 10.2147/DDDT.S332623. eCollection 2021.
Sepsis is the leading condition associated with acute kidney injury (AKI) in the hospital and intensive care unit (ICU), sepsis-induced AKI (S-AKI) is strongly associated with poor clinical outcomes. Curcumin possesses an ability to ameliorate renal injury from ischemia-reperfusion, but it is still unknown whether they have the ability to reduce S-AKI. The aim of this study was to investigate the protective effects of curcumin on S-AKI and to assess its therapeutic potential on renal function, inflammatory response, and microcirculatory perfusion.
Male Sprague-Dawley (SD) rats underwent cecal ligation and puncture (CLP) to induce S-AKI and immediately received vehicle (CLP group) or curcumin (CLP+Cur group) after surgery. At 12 and 24h after surgery, serum indexes, inflammatory factors, cardiac output (CO), renal blood flow and microcirculatory flow were measured.
Serum levels of creatinine (Scr), cystatin C (CysC), IL-6 and TNF-α were significantly lower in the CLP+Cur group than those in the CLP group (P < 0.05). Treatment with curcumin improved renal microcirculation at 24h by measurement of contrast enhanced ultrasound (CEUS) quantitative parameters [peak intensity (PI); half of descending time (DT/2); area under curve (AUC); P < 0.05]. In histopathological analysis, treatment with curcumin reduced damage caused by CLP.
Curcumin can alleviate S-AKI in rats by improving renal microcirculatory perfusion and reducing inflammatory response. Curcumin may be a potential novel therapeutic agent for the prevention or reduction of S-AKI.
脓毒症是医院和重症监护病房（ICU）中与急性肾损伤（AKI）相关的主要疾病，脓毒症引起的 AKI（S-AKI）与不良临床结局密切相关。姜黄素具有减轻肾缺血再灌注损伤的能力，但尚不清楚其是否具有减轻 S-AKI 的能力。本研究旨在探讨姜黄素对 S-AKI 的保护作用，并评估其对肾功能、炎症反应和微循环灌注的治疗潜力。
雄性 Sprague-Dawley（SD）大鼠行盲肠结扎穿孔（CLP）以诱导 S-AKI，并在手术后立即给予载体（CLP 组）或姜黄素（CLP+Cur 组）。术后 12 和 24h 测量血清指标、炎症因子、心输出量（CO）、肾血流量和微循环灌注。
CLP+Cur 组血清肌酐（Scr）、胱抑素 C（CysC）、IL-6 和 TNF-α水平明显低于 CLP 组（P<0.05）。姜黄素治疗可通过对比增强超声（CEUS）定量参数改善 24h 时的肾脏微循环[峰值强度（PI）；下降时间的一半（DT/2）；曲线下面积（AUC）；P<0.05]。组织病理学分析显示，姜黄素治疗减轻了 CLP 引起的损伤。
姜黄素通过改善肾微循环灌注和减轻炎症反应，可减轻大鼠 S-AKI。姜黄素可能是预防或减轻 S-AKI 的一种有潜力的新型治疗药物。
