Yang Yuhang, Deng Xinqi, Li Wenyuan, Leng Yan, Xiong Yonghong, Wang Bihan, Gong Siyuan, Wang Yunhao, Yang Baichuan, Li Wei
Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
Clin Epigenetics. 2025 Apr 6;17(1):57. doi: 10.1186/s13148-025-01861-9.
Sepsis is a syndrome of organ dysfunction caused by the invasion of pathogenic microorganisms. In clinical practice, patients with sepsis are prone to concurrent acute kidney injury, which has high morbidity and mortality rates. Thus, understanding the pathogenesis of sepsis-associated acute kidney injury is of significant clinical importance. Ferroptosis is an iron-dependent programmed cell death pathway, which is proved to play a critical role in the process of sepsis-associated acute kidney injury through various mechanisms. Epigenetic regulation modulates the content and function of nucleic acids and proteins within cells through various modifications. Its impact on ferroptosis has garnered increasing attention; however, the role of epigenetic regulation targeting ferroptosis in sepsis-associated acute kidney injury has not been fully elucidated. Growing evidence suggests that epigenetic regulation can modulate ferroptosis through complex pathway networks, thereby affecting the development and prognosis of sepsis-associated acute kidney injury. This paper summarizes the impact of ferroptosis on sepsis-associated acute kidney injury and the regulatory mechanisms of epigenetic regulation on ferroptosis, providing new insights for the targeted therapy of sepsis-associated acute kidney injury.
脓毒症是由病原微生物入侵引起的器官功能障碍综合征。在临床实践中，脓毒症患者易并发急性肾损伤，其发病率和死亡率都很高。因此，了解脓毒症相关性急性肾损伤的发病机制具有重要的临床意义。铁死亡是一种铁依赖性程序性细胞死亡途径，已证明其通过多种机制在脓毒症相关性急性肾损伤过程中起关键作用。表观遗传调控通过各种修饰调节细胞内核酸和蛋白质的含量及功能。其对铁死亡的影响日益受到关注；然而，针对铁死亡的表观遗传调控在脓毒症相关性急性肾损伤中的作用尚未完全阐明。越来越多的证据表明，表观遗传调控可通过复杂的信号通路网络调节铁死亡，从而影响脓毒症相关性急性肾损伤的发生发展及预后。本文综述了铁死亡对脓毒症相关性急性肾损伤的影响以及表观遗传调控对铁死亡的调节机制，为脓毒症相关性急性肾损伤的靶向治疗提供新的思路。
