Zhao Xiliang, Li Xiaoli, Li Quan, Ye Yicong, Zeng Yong
Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, People's Republic of China.
Department of Cardiology, Rugao Hospital of Traditional Chinese Medicine, Jiangsu, 226500, People's Republic of China.
Int J Gen Med. 2021 Oct 5;14:6359-6365. doi: 10.2147/IJGM.S330400. eCollection 2021.
Mean platelet volume (MPV) is an indicator of platelet activation. Pancreatic β-cell dysfunction is one of the fundamental defects contributing to the development of type 2 diabetes. The aim of this study was to assess the relationship between β-cell dysfunction and MPV in nondiabetic patients with coronary artery disease (CAD).
A total of 1143 consecutive nondiabetic patients (874 males and 269 females; mean age 60.0±10.3 years) with CAD were recruited for this analysis. All patients were individuals who underwent coronary angiography with a suspicion of CAD. Homeostatic model assessment 2 (HOMA2) of β-cell function (HOMA2-β%) was performed, and β-cell dysfunction was defined by a HOMA2-β% in the lowest quartile.
MPV was significantly higher in CAD patients with β-cell dysfunction than in controls [(10.6±1.0)fl vs (10.0±1.0)fl, P=0.011]. According to the multiple regression model, pancreatic β-cell dysfunction was independently associated with MPV (β=0.210, P=0.006) and age (β=0.008, P=0.028).
MPV was significantly elevated in nondiabetic CAD patients with β-cell dysfunction compared to patients with normal β-cell function.
平均血小板体积（MPV）是血小板活化的一个指标。胰腺β细胞功能障碍是导致2型糖尿病发生的基本缺陷之一。本研究的目的是评估非糖尿病冠心病（CAD）患者中β细胞功能障碍与MPV之间的关系。
本分析共纳入1143例连续的非糖尿病CAD患者（男性874例，女性269例；平均年龄60.0±10.3岁）。所有患者均为因怀疑CAD而接受冠状动脉造影的个体。进行了β细胞功能的稳态模型评估2（HOMA2）（HOMA2-β%），β细胞功能障碍定义为HOMA2-β%处于最低四分位数。
β细胞功能障碍的CAD患者的MPV显著高于对照组[（10.6±1.0）fl对（10.0±1.0）fl，P = 0.011]。根据多元回归模型，胰腺β细胞功能障碍与MPV（β = 0.210，P = 0.006）和年龄（β = 0.008，P = 0.028）独立相关。
与β细胞功能正常的患者相比，β细胞功能障碍的非糖尿病CAD患者的MPV显著升高。
