• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种用于预测皮肤黑色素瘤预后的新型焦亡相关长链非编码RNA特征

A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma.

作者信息

Xie Jiaheng, Li Haobo, Chen Liang, Cao Yuan, Hu Yiming, Zhu Zhechen, Wang Ming, Shi Jingping

机构信息

Department of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

出版信息

Int J Gen Med. 2021 Oct 8;14:6517-6527. doi: 10.2147/IJGM.S335396. eCollection 2021.

DOI:10.2147/IJGM.S335396
PMID:34675619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8518699/
Abstract

PURPOSE

To construct a prognosis model of melanoma based on pyroptosis related genes.

METHODS

Melanoma RNA-sequencing data was downloaded from TCGA. First, the lnRNAs related to pyroptosis were obtained through Pearson correlation analysis. Then, the prognosis model of pyroptosis related genes was constructed by Cox regression and Lasso regression. Melanoma patients were divided into high-risk and low-risk groups by risk score, and the differences in prognosis and immune microenvironment between the two groups were explored.

RESULTS

We found that the high-risk group had a significantly poorer prognosis, and different groups differed in immune infiltration, m6A methylation, and immune checkpoint.

CONCLUSION

Our prognostic model can provide a reference for the study of pyroptosis in melanoma cells and provide a new idea for melanoma treatment.

摘要

目的

构建基于焦亡相关基因的黑色素瘤预后模型。

方法

从TCGA下载黑色素瘤RNA测序数据。首先，通过Pearson相关分析获得与焦亡相关的lnRNA。然后，通过Cox回归和Lasso回归构建焦亡相关基因的预后模型。根据风险评分将黑色素瘤患者分为高风险组和低风险组，探讨两组之间预后和免疫微环境的差异。

结果

我们发现高风险组的预后明显较差，不同组在免疫浸润、m6A甲基化和免疫检查点方面存在差异。

结论

我们的预后模型可为黑色素瘤细胞焦亡的研究提供参考，并为黑色素瘤治疗提供新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/bc41ce314e31/IJGM-14-6517-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/e42d240a08ca/IJGM-14-6517-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/2384467258a4/IJGM-14-6517-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/f89596f1798c/IJGM-14-6517-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/29984320d054/IJGM-14-6517-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/3f7865d32c58/IJGM-14-6517-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/bc41ce314e31/IJGM-14-6517-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/e42d240a08ca/IJGM-14-6517-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/2384467258a4/IJGM-14-6517-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/f89596f1798c/IJGM-14-6517-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/29984320d054/IJGM-14-6517-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/3f7865d32c58/IJGM-14-6517-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae2/8518699/bc41ce314e31/IJGM-14-6517-g0006.jpg

相似文献

1
A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma.一种用于预测皮肤黑色素瘤预后的新型焦亡相关长链非编码RNA特征
Int J Gen Med. 2021 Oct 8;14:6517-6527. doi: 10.2147/IJGM.S335396. eCollection 2021.
2
Identification of a pyroptosis-associated long non-coding RNA signature for predicting the immune status and prognosis in skin cutaneous melanoma.鉴定一个与细胞焦亡相关的长非编码 RNA 特征，用于预测皮肤黑色素瘤的免疫状态和预后。
Eur Rev Med Pharmacol Sci. 2021 Sep;25(18):5597-5609. doi: 10.26355/eurrev_202109_26779.
3
Construction and validation of a novel pyroptosis-related signature to predict prognosis in patients with cutaneous melanoma.构建并验证一个新的与细胞焦亡相关的标志物，用于预测皮肤黑色素瘤患者的预后。
Math Biosci Eng. 2022 Jan;19(1):688-706. doi: 10.3934/mbe.2022031. Epub 2021 Nov 19.
4
Using Immune-Related lncRNA Signature for Prognosis and Response to Immunotherapy in Cutaneous Melanoma.利用免疫相关长链非编码RNA特征预测皮肤黑色素瘤的预后及免疫治疗反应
Int J Gen Med. 2021 Oct 8;14:6463-6475. doi: 10.2147/IJGM.S335266. eCollection 2021.
5
A novel pyroptosis-related LncRNA signature predicts prognosis and indicates tumor immune microenvironment in skin cutaneous melanoma.一个新的与细胞焦亡相关的长链非编码 RNA 特征可预测皮肤黑色素瘤的预后并提示肿瘤免疫微环境。
Life Sci. 2022 Oct 15;307:120832. doi: 10.1016/j.lfs.2022.120832. Epub 2022 Aug 5.
6
A pyroptosis-related lncRNA signature predicts prognosis and immune microenvironment in head and neck squamous cell carcinoma.一种与焦亡相关的长链非编码RNA特征可预测头颈部鳞状细胞癌的预后和免疫微环境。
Int Immunopharmacol. 2021 Dec;101(Pt B):108268. doi: 10.1016/j.intimp.2021.108268. Epub 2021 Oct 20.
7
A novel pyroptosis-associated gene signature for immune status and prognosis of cutaneous melanoma.一种用于评估皮肤黑色素瘤免疫状态和预后的新型细胞焦亡相关基因特征
PeerJ. 2021 Oct 14;9:e12304. doi: 10.7717/peerj.12304. eCollection 2021.
8
A new pyroptosis model can predict the immunotherapy response and immune microenvironment characteristics and prognosis of patients with cutaneous melanoma based on TCGA and GEO databases.一种新的细胞焦亡模型能够基于TCGA和GEO数据库预测皮肤黑色素瘤患者的免疫治疗反应、免疫微环境特征及预后。
Ann Transl Med. 2022 Mar;10(6):353. doi: 10.21037/atm-22-1095.
9
Identification of a Novel Pyroptosis-Related Gene Signature Indicative of Disease Prognosis and Treatment Response in Skin Cutaneous Melanoma.一种新型细胞焦亡相关基因特征的鉴定，该特征可指示皮肤黑色素瘤的疾病预后和治疗反应
Int J Gen Med. 2022 Jul 12;15:6145-6163. doi: 10.2147/IJGM.S367693. eCollection 2022.
10
Pyroptosis-Related LncRNA Signatures Correlate With Lung Adenocarcinoma Prognosis.焦亡相关长链非编码RNA特征与肺腺癌预后相关。
Front Oncol. 2022 Mar 2;12:850943. doi: 10.3389/fonc.2022.850943. eCollection 2022.

引用本文的文献

1
The role of non-coding RNAs in the regulation of cell death pathways in melanoma.非编码RNA在黑色素瘤细胞死亡途径调控中的作用
Discov Oncol. 2025 Jun 11;16(1):1063. doi: 10.1007/s12672-025-02888-3.
2
A signature of seven hypoxia-related lncRNAs is a potential biomarker for predicting the prognosis of melanoma.七种缺氧相关长链非编码RNA的特征是预测黑色素瘤预后的潜在生物标志物。
Am J Cancer Res. 2024 Apr 15;14(4):1712-1729. doi: 10.62347/LHKW3124. eCollection 2024.
3
Multi-dimensional characterization of apoptosis in the tumor microenvironment and therapeutic relevance in melanoma.

本文引用的文献

1
A pan-cancer analysis revealed the role of the SLC16 family in cancer.泛癌分析揭示了 SLC16 家族在癌症中的作用。
Channels (Austin). 2021 Dec;15(1):528-540. doi: 10.1080/19336950.2021.1965422.
2
Database mining analysis revealed the role of the putative H/sugar transporter solute carrier family 45 in skin cutaneous melanoma.数据库挖掘分析揭示了假定的 H/糖转运蛋白溶质载体家族 45 在皮肤黑色素瘤中的作用。
Channels (Austin). 2021 Dec;15(1):496-506. doi: 10.1080/19336950.2021.1956226.
3
Solute carrier transporter superfamily member SLC16A1 is a potential prognostic biomarker and associated with immune infiltration in skin cutaneous melanoma.
肿瘤微环境中细胞凋亡的多维特征及其在黑色素瘤治疗中的相关性
Cell Oncol (Dordr). 2024 Aug;47(4):1333-1353. doi: 10.1007/s13402-024-00930-0. Epub 2024 Mar 19.
4
Prognostic model development and molecular subtypes identification in bladder urothelial cancer by oxidative stress signatures.基于氧化应激特征的膀胱癌预后模型建立及分子亚型鉴定
Aging (Albany NY). 2024 Feb 1;16(3):2591-2616. doi: 10.18632/aging.205499.
5
Prognostic Significance of Glycolysis-Related Genes in Lung Squamous Cell Carcinoma.糖酵解相关基因在肺鳞癌中的预后意义。
Int J Mol Sci. 2024 Jan 17;25(2):1143. doi: 10.3390/ijms25021143.
6
THEM6 is a prognostic biomarker for breast cancer and is associated with immune infiltration.THEM6 是乳腺癌的预后生物标志物，与免疫浸润有关。
Sci Rep. 2023 Dec 11;13(1):21974. doi: 10.1038/s41598-023-49379-5.
7
Clinical-mediated discovery of pyroptosis in CD8 T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence.临床介导的 CD8 T 细胞和 NK 细胞焦亡发现揭示了单细胞和批量测序的黑色素瘤异质性。
Cell Death Dis. 2023 Aug 24;14(8):553. doi: 10.1038/s41419-023-06068-5.
8
Psoriasis Associated Hub Genes Revealed by Weighted Gene Co-Expression Network Analysis.加权基因共表达网络分析揭示的银屑病相关枢纽基因
Cell J. 2023 Jun 28;25(6):418-426. doi: 10.22074/cellj.2023.1982769.1191.
9
A BRAF mutation-associated gene risk model for predicting the prognosis of melanoma.一种用于预测黑色素瘤预后的BRAF突变相关基因风险模型。
Heliyon. 2023 May 2;9(5):e15939. doi: 10.1016/j.heliyon.2023.e15939. eCollection 2023 May.
10
Identification of m6A regulator-mediated RNA methylation modification patterns and key immune-related genes involved in atrial fibrillation.鉴定 m6A 调节子介导的 RNA 甲基化修饰模式及心房颤动中涉及的关键免疫相关基因。
Aging (Albany NY). 2023 Feb 20;15(5):1371-1393. doi: 10.18632/aging.204537.
溶质载体家族 16 成员 1 是皮肤黑色素瘤的一个潜在预后生物标志物，与免疫浸润相关。
Channels (Austin). 2021 Dec;15(1):483-495. doi: 10.1080/19336950.2021.1953322.
4
Role of m6A RNA methylation in cardiovascular disease (Review).m6A RNA 甲基化在心血管疾病中的作用（综述）。
Int J Mol Med. 2020 Dec;46(6):1958-1972. doi: 10.3892/ijmm.2020.4746. Epub 2020 Oct 6.
5
Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy.用仿生纳米颗粒编程细胞焦亡用于实体瘤免疫治疗
Biomaterials. 2020 Sep;254:120142. doi: 10.1016/j.biomaterials.2020.120142. Epub 2020 May 28.
6
Mechanism and regulation of pyroptosis-mediated in cancer cell death.细胞焦亡介导的癌细胞死亡的机制和调控。
Chem Biol Interact. 2020 May 25;323:109052. doi: 10.1016/j.cbi.2020.109052. Epub 2020 Mar 10.
7
Melanoma Metabolism: Cell Survival and Resistance to Therapy.黑色素瘤代谢：细胞存活与治疗抵抗
Adv Exp Med Biol. 2020;1219:203-223. doi: 10.1007/978-3-030-34025-4_11.
8
Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus.程序性细胞死亡通路在系统性红斑狼疮发病机制中的作用。
J Immunol Res. 2019 Dec 1;2019:3638562. doi: 10.1155/2019/3638562. eCollection 2019.
9
Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis.突变 BRAF 和 MEK 抑制剂通过细胞焦亡调节肿瘤免疫微环境。
Cancer Discov. 2020 Feb;10(2):254-269. doi: 10.1158/2159-8290.CD-19-0672. Epub 2019 Dec 3.
10
The interplay between m6A RNA methylation and noncoding RNA in cancer.m6A RNA 甲基化与癌症中非编码 RNA 的相互作用。
J Hematol Oncol. 2019 Nov 22;12(1):121. doi: 10.1186/s13045-019-0805-7.