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对真皮注射脐带血来源间充质干细胞生长因子的肉芽肿反应：一例报告

Granulomatous Reaction to Dermal Injection of Growth Factors from Umbilical Cord Blood-Derived Mesenchymal Stem Cells: A Case Report.

作者信息

Yang Hee Joo, Na Hyoungmin, Lee Woo Jin, Chang Sung Eun, Lee Mi Woo, Won Chong Hyun

机构信息

Department of Dermatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

出版信息

Int Med Case Rep J. 2021 Oct 5;14:719-723. doi: 10.2147/IMCRJ.S324357. eCollection 2021.

DOI:10.2147/IMCRJ.S324357
PMID:34675690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8502046/
Abstract

Use of stem cells to treat various diseases in dermatology has been of interest. Conditioned media with the growth factors secreted from stem cells has been used as a topical agent. We report a case of foreign body granulomas that appeared days after dermal injection of the conditioned media mimicking scars at all injection sites.

摘要

利用干细胞治疗皮肤病学中的各种疾病一直备受关注。含有干细胞分泌的生长因子的条件培养基已被用作一种局部用药。我们报告了一例在真皮注射条件培养基数天后出现异物肉芽肿的病例，所有注射部位均出现类似瘢痕的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffc/8502046/e35bf9c8a4a2/IMCRJ-14-719-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffc/8502046/7d9d80124f93/IMCRJ-14-719-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffc/8502046/c35b55d96b12/IMCRJ-14-719-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffc/8502046/e35bf9c8a4a2/IMCRJ-14-719-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffc/8502046/7d9d80124f93/IMCRJ-14-719-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffc/8502046/c35b55d96b12/IMCRJ-14-719-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffc/8502046/e35bf9c8a4a2/IMCRJ-14-719-g0003.jpg

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本文引用的文献

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Granulomas and nongranulomatous nodules after filler injection: Different complications require different treatments.填充剂注射后出现的肉芽肿和非肉芽肿性结节：不同的并发症需要不同的治疗方法。
J Plast Reconstr Aesthet Surg. 2020 Nov;73(11):2010-2015. doi: 10.1016/j.bjps.2020.08.012. Epub 2020 Aug 13.
2
Delayed sclerosing granulomatous reaction to dermal filler injection of poly-hydroxyethyl-methacrylate suspended in hyaluronic acid: Histochemical and confocal laser scanning microscopical analysis.对注射于透明质酸中的聚甲基丙烯酸羟乙酯真皮填充剂的延迟性硬化性肉芽肿反应：组织化学及共聚焦激光扫描显微镜分析
Clin Case Rep. 2019 Oct 7;7(11):2215-2219. doi: 10.1002/ccr3.2478. eCollection 2019 Nov.
3
[Subcutaneous foreign body granuloma after neck dissection and adjuvant radiation].
[颈部清扫术及辅助放疗后皮下异物肉芽肿]
HNO. 2019 Dec;67(12):948-951. doi: 10.1007/s00106-019-0700-0.
4
Efficacy of stem cell-conditioned medium platelet-rich plasma as an adjuvant to ablative fractional CO laser resurfacing for atrophic post-acne scars: a split-face clinical trial.干细胞条件培养基联合富血小板血浆作为剥脱性分数二氧化碳激光换肤治疗萎缩性痤疮瘢痕辅助治疗的疗效：一项半脸临床试验。
J Dermatolog Treat. 2021 Mar;32(2):242-249. doi: 10.1080/09546634.2019.1630701. Epub 2019 Jul 5.
5
Objective analysis of volume restoration in atrophic acne scars and skin pores: a split study using human stem cell-conditioned media.目的分析萎缩性痤疮瘢痕和皮肤毛孔的体积恢复：使用人干细胞条件培养基的分割研究。
J Dermatolog Treat. 2021 Feb;32(1):73-77. doi: 10.1080/09546634.2019.1628915. Epub 2019 Jul 5.
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J Tissue Eng Regen Med. 2019 Apr;13(4):569-586. doi: 10.1002/term.2806. Epub 2019 Mar 20.
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