Chen Miaomiao, Lai Xingning, Wang Xifeng, Ying Jun, Zhang Lieliang, Zhou Bin, Liu Xing, Zhang Jing, Wei Gen, Hua Fuzhou
Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China.
Front Mol Neurosci. 2021 Oct 5;14:745066. doi: 10.3389/fnmol.2021.745066. eCollection 2021.
Microglia and astrocytes maintain tissue homeostasis in the nervous system. Both microglia and astrocytes have pro-inflammatory phenotype and anti-inflammatory phenotype. Activated microglia and activated astrocytes can contribute to several neurological diseases. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), two groups of non-coding RNAs (ncRNAs), can function as competing endogenous RNAs (ceRNAs) to impair the microRNA (miRNA) inhibition on targeted messenger RNAs (mRNAs). LncRNAs and circRNAs are involved in various neurological disorders. In this review, we summarized that lncRNAs and circRNAs participate in microglia dysfunction, astrocyte dysfunction, neuron damage, and inflammation. Thereby, lncRNAs and circRNAs can positively or negatively regulate neurological diseases, including spinal cord injury (SCI), traumatic brain injury (TBI), ischemia-reperfusion injury (IRI), stroke, neuropathic pain, epilepsy, Parkinson's disease (PD), multiple sclerosis (MS), and Alzheimer's disease (AD). Besides, we also found a lncRNA/circRNA-miRNA-mRNA regulatory network in microglia and astrocyte mediated neurological diseases. Through this review, we hope to cast light on the regulatory mechanisms of lncRNAs and circRNAs in microglia and astrocyte mediated neurological diseases and provide new insights for neurological disease treatment.
小胶质细胞和星形胶质细胞维持神经系统的组织稳态。小胶质细胞和星形胶质细胞都具有促炎表型和抗炎表型。活化的小胶质细胞和活化的星形胶质细胞可导致多种神经疾病。长链非编码RNA（lncRNA）和环状RNA（circRNA）这两类非编码RNA（ncRNA）可作为竞争性内源RNA（ceRNA）发挥作用，削弱微小RNA（miRNA）对靶向信使RNA（mRNA）的抑制作用。lncRNA和circRNA参与多种神经疾病。在本综述中，我们总结了lncRNA和circRNA参与小胶质细胞功能障碍、星形胶质细胞功能障碍、神经元损伤和炎症。因此，lncRNA和circRNA可正向或负向调节包括脊髓损伤（SCI）、创伤性脑损伤（TBI）、缺血再灌注损伤（IRI）、中风、神经性疼痛、癫痫、帕金森病（PD）、多发性硬化症（MS）和阿尔茨海默病（AD）在内的神经疾病。此外，我们还发现了小胶质细胞和星形胶质细胞介导的神经疾病中的lncRNA/circRNA-miRNA-mRNA调控网络。通过本综述，我们希望阐明lncRNA和circRNA在小胶质细胞和星形胶质细胞介导的神经疾病中的调控机制，并为神经疾病治疗提供新的见解。
