He Liang, Zhang Furong, Zhu Yuling, Lu Meilin
Department of Anesthesiology, Yan'an Hospital of Kunming City, Kunming Medical University, Kunming, China.
Department of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Front Mol Neurosci. 2022 Oct 18;15:960657. doi: 10.3389/fnmol.2022.960657. eCollection 2022.
Patients with Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury (TBI), stroke, and postoperative neurocognitive disorder (POND) are commonly faced with neurocognitive disorders with limited therapeutic options. Some non-coding ribonucleic acids (ncRNAs) are involved in the development of various brain cognitive disorders. Circular RNAs (circRNAs), a typical group of ncRNAs, can function as competitive endogenous RNAs (ceRNAs) to dysregulate shared microRNAs (miRNAs) at post-transcription level, inhibiting regulation of miRNAs on their targeted messenger RNAs (mRNAs). circRNAs are abundant in central nervous system (CNS) diseases and cause brain disorders, but the exact roles of circRNAs are unclear. The crosstalk between circRNA, miRNA, and mRNA plays an important role in the pathogenesis of these neurocognitive dysfunction diseases and abnormal conditions including AD, PD, stroke, TBI, and POND. In this review, we summarized the participation of circRNA in neuroglial damage and inflammation. Finally, we aimed to highlight the regulatory mechanisms of circRNA-miRNA-mRNA networks in the development of various brain cognitive disorders and provide new insights into the therapeutics of these diseases.
患有阿尔茨海默病（AD）、帕金森病（PD）、创伤性脑损伤（TBI）、中风和术后神经认知障碍（POND）的患者通常面临神经认知障碍，且治疗选择有限。一些非编码核糖核酸（ncRNAs）参与了各种脑认知障碍的发展。环状RNA（circRNAs）是一类典型的ncRNAs，可作为竞争性内源性RNA（ceRNAs）在转录后水平失调共享的微小RNA（miRNAs），抑制miRNAs对其靶向信使RNA（mRNAs）的调控。circRNAs在中枢神经系统（CNS）疾病中大量存在并导致脑部疾病，但其确切作用尚不清楚。circRNA、miRNA和mRNA之间的相互作用在这些神经认知功能障碍疾病以及包括AD、PD、中风、TBI和POND在内的异常情况的发病机制中起重要作用。在本综述中，我们总结了circRNA在神经胶质损伤和炎症中的参与情况。最后，我们旨在强调circRNA-miRNA-mRNA网络在各种脑认知障碍发展中的调控机制，并为这些疾病的治疗提供新的见解。
