Zheng Cao, Zhang Rong-Sheng, Wan Ting, Zhao Jun-Sheng
Department of Radiation Intervention, Central Hospital of Huanggang City, Huanggang, China.
Department of Radiology, Central Hospital of Huanggang City, Huanggang, China.
Front Aging Neurosci. 2021 Oct 4;13:741445. doi: 10.3389/fnagi.2021.741445. eCollection 2021.
Aneurysmal subarachnoid hemorrhage (aSAH) is a common disease causing vascular dementia. Survivors often suffer from cognitive impairment especially working memory deficit. Currently, lack of theoretical support limits the improvement of cognitive intervention or rehabilitation. It is unclear how the large-scale network differs and to what extent is the brain network affected? Our study aims to provide novel information about the topological characteristics of brain organization, especially "small-world" property. A total of 62 aSAH patients are enrolled in this study. They are divided into two groups according to the syndrome of working memory deficit. Their working memory function is evaluated by TMT-B and AVLT (Chinese version). Functional MRI scan is also performed for detecting resting-state cortical plasticity. We utilized ICA to extract functional sub-networks including working memory network from imaging data. And then we establish binarized network and calculate the small-worldness property as well as local and global efficiency of networks. aSAH group with working memory deficit shows no significant difference of clustering coefficient with control group. Our study discovered significant decrease of characteristic path length indicating an increase of overall routing efficiency. We reason that patients with working memory deficit have to recruit more neuronal resources and thus develops higher overall routing efficiency of local network. This study provides novel information about the neural alterations of aSAH patients with working memory deficit. It might contribute to the understanding of neural mechanism and the improvement of current intervention for vascular dementia.
动脉瘤性蛛网膜下腔出血（aSAH）是导致血管性痴呆的常见疾病。幸存者常患有认知障碍，尤其是工作记忆缺陷。目前，缺乏理论支持限制了认知干预或康复的改善。尚不清楚大规模网络如何不同以及脑网络受影响的程度如何？我们的研究旨在提供有关脑组织拓扑特征的新信息，特别是“小世界”特性。本研究共纳入62例aSAH患者。根据工作记忆缺陷综合征将他们分为两组。通过TMT-B和AVLT（中文版）评估他们的工作记忆功能。还进行功能磁共振成像扫描以检测静息态皮质可塑性。我们利用独立成分分析（ICA）从成像数据中提取包括工作记忆网络在内的功能子网。然后我们建立二值化网络并计算网络的小世界特性以及局部和全局效率。有工作记忆缺陷的aSAH组与对照组相比，聚类系数无显著差异。我们的研究发现特征路径长度显著缩短，表明整体路由效率提高。我们推测，有工作记忆缺陷的患者必须募集更多的神经元资源，从而提高局部网络的整体路由效率。本研究提供了有关有工作记忆缺陷的aSAH患者神经改变的新信息。它可能有助于理解神经机制并改善目前对血管性痴呆的干预。
