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Biochem Biophys Res Commun. 2020 May 14;525(4):841-849. doi: 10.1016/j.bbrc.2020.02.100. Epub 2020 Mar 11.
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Life Sci. 2020 Mar 1;244:117179. doi: 10.1016/j.lfs.2019.117179. Epub 2019 Dec 19.
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CircRNA cRAPGEF5 inhibits the growth and metastasis of renal cell carcinoma via the miR-27a-3p/TXNIP pathway.环状 RNA cRAPGEF5 通过 miR-27a-3p/TXNIP 通路抑制肾细胞癌的生长和转移。
Cancer Lett. 2020 Jan 28;469:68-77. doi: 10.1016/j.canlet.2019.10.017. Epub 2019 Oct 17.
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Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression.环状 RNA circTADA2A 通过海绵吸附 miR-203a-3p 和调控 CREB3 表达促进骨肉瘤的进展和转移。
Mol Cancer. 2019 Apr 2;18(1):73. doi: 10.1186/s12943-019-1007-1.
5
Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression.环状 RNA AKT3 通过抑制 miR-198 上调 PIK3R1 以增强胃癌对顺铂的耐药性。
Mol Cancer. 2019 Mar 30;18(1):71. doi: 10.1186/s12943-019-0969-3.
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Upregulated circ RNA hsa_circ_0000337 promotes cell proliferation, migration, and invasion of esophageal squamous cell carcinoma.上调的环状RNA hsa_circ_0000337促进食管鳞状细胞癌的细胞增殖、迁移和侵袭。
Cancer Manag Res. 2019 Mar 4;11:1997-2006. doi: 10.2147/CMAR.S195546. eCollection 2019.
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CircRNA circ_0067934 Overexpression Correlates with Poor Prognosis and Promotes Thyroid Carcinoma Progression.环状 RNA circ_0067934 过表达与不良预后相关，并促进甲状腺癌进展。
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8
A circular RNA hsa_circ_0079929 inhibits tumor growth in hepatocellular carcinoma.环状RNA hsa_circ_0079929抑制肝细胞癌的肿瘤生长。
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10
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Biochem Biophys Res Commun. 2019 Jan 22;508(4):991-996. doi: 10.1016/j.bbrc.2018.12.046. Epub 2018 Dec 11.

circSLC30A7 Inhibits Hepatocellular Carcinoma Cell Proliferation via the miR-767-5p/FBXW7/NOTCH1 Axis.

作者信息

Yu Xiaotian, Zhang Yun, Jiang Chao, Zhan Feng, Shen Zhenwei, Shen Zhenghai, Zhang Feng

机构信息

Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Department of General Surgery, The Affiliated Yixing Hospital of Jiangsu University, Wuxi, China.

出版信息

J Oncol. 2021 Oct 12;2021:8800657. doi: 10.1155/2021/8800657. eCollection 2021.

DOI:10.1155/2021/8800657
PMID:34675978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8526270/
Abstract

Circular RNAs, noncoding RNAs, have attracted much attention in various human tumor research fields. They regulate the development of various human cancers via microRNA sponges. This study aimed to assess the molecular mechanism of circSLC30A7 in hepatocellular carcinoma (HCC). In our study, we identified that circSLC30A7 was significantly downregulated in HCC cell lines and tissues. Furthermore, gain and loss function experiments were conducted to elucidate the biological functions of circSLC30A7 in HCC cell lines. Mechanistically, circSLC30A7 sponged miR-767-5p, inhibiting the expression of its downstream protein, FBXW7. In summary, this study revealed that circSLC30A7 is an essential tumor suppressor that inhibits HCC tumorigenesis through the miR-767-5p/FBXW7/NOTCH1 axis. Taken together, circSLC30A7 reduces HCC malignancy and can be a biomarker for HCC management.

摘要