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在日常情况下模拟人类对真菌毒素脱氧雪腐镰刀菌烯醇的肾脏排泄。

Modelling the Renal Excretion of the Mycotoxin Deoxynivalenol in Humans in an Everyday Situation.

机构信息

National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, The Netherlands.

Norwegian Veterinary Institute (NVI), P.O. Box 64, 1431 Ås, Norway.

出版信息

Toxins (Basel). 2021 Sep 22;13(10):675. doi: 10.3390/toxins13100675.

DOI:10.3390/toxins13100675
PMID:34678968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8540402/
Abstract

The dietary exposure to the mycotoxin deoxynivalenol (DON) can be assessed by human biomonitoring (HBM). Here, we assessed the relation between dietary DON intake and the excretion of its major metabolite DON-15-glucuronide (DON15GlcA) through time, in an everyday situation. For 49 volunteers from the EuroMix biomonitoring study, the intake of DON from each meal was calculated and the excretion of DON and its metabolites was analyzed for each urine void collected separately throughout a 24-h period. The relation between DON and DON15GlcA was analyzed with a statistical model to assess the residence time and the excreted fraction of ingested DON as DON15GlcA (f). F was treated as a random effect variable to address its heterogeneity in the population. The estimated time in which 97.5% of the ingested DON was excreted as DON15GlcA was 12.1 h, the elimination half-life was 4.0 h. Based on the estimated f, the mean reversed dosimetry factor (RDF) of DON15GlcA was 2.28. This RDF can be used to calculate the amount of total DON intake in an everyday situation, based on the excreted amount of DON15GlcA. We show that urine samples collected over 24 h are the optimal design to study DON exposure by HBM.

摘要

膳食中脱氧雪腐镰刀菌烯醇（DON）的暴露可通过人体生物监测（HBM）进行评估。在这里，我们评估了在日常情况下，膳食 DON 摄入量与 DON 的主要代谢物 DON-15-葡萄糖醛酸（DON15GlcA）排泄之间随时间的关系。在 EuroMix 生物监测研究的 49 名志愿者中，我们计算了每餐摄入的 DON 量，并分析了每个 24 小时尿液样本中 DON 及其代谢物的排泄情况。我们使用统计模型分析 DON 与 DON15GlcA 之间的关系，以评估摄入 DON 转化为 DON15GlcA 的停留时间和排泄分数（f）。f 被视为随机变量，以解决其在人群中的异质性。97.5%的摄入 DON 转化为 DON15GlcA 的估计时间为 12.1 小时，消除半衰期为 4.0 小时。基于估计的 f，DON15GlcA 的平均反向剂量因子（RDF）为 2.28。该 RDF 可用于根据 DON15GlcA 的排泄量计算日常情况下摄入的总 DON 量。我们表明，收集 24 小时尿液样本是通过 HBM 研究 DON 暴露的最佳设计。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/73dc11e1f09b/toxins-13-00675-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/944c3e1c1bce/toxins-13-00675-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/84d87a4316be/toxins-13-00675-g0A2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/65666d3f2c94/toxins-13-00675-g0A3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/1801386c661a/toxins-13-00675-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/38f35560ce4a/toxins-13-00675-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/73dc11e1f09b/toxins-13-00675-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/944c3e1c1bce/toxins-13-00675-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/84d87a4316be/toxins-13-00675-g0A2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/65666d3f2c94/toxins-13-00675-g0A3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/1801386c661a/toxins-13-00675-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/38f35560ce4a/toxins-13-00675-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfb/8540402/73dc11e1f09b/toxins-13-00675-g003.jpg

相似文献

[1]
Modelling the Renal Excretion of the Mycotoxin Deoxynivalenol in Humans in an Everyday Situation.

Toxins (Basel). 2021-9-22

[2]
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Toxins (Basel). 2024-3-7

[3]
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Environ Int. 2015-7-30

[4]
Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours.

Sci Rep. 2018-3-27

[5]
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Toxins (Basel). 2019-8-8

[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Human Biomonitoring Guidance Values for Deoxynivalenol Derived under the European Human Biomonitoring Initiative (HBM4EU).

Toxins (Basel). 2024-3-7

[2]
Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling: A case study with the mycotoxin deoxynivalenol.

Environ Int. 2023-12

[3]
Development of a Generic PBK Model for Human Biomonitoring with an Application to Deoxynivalenol.

Toxins (Basel). 2023-9-13

[4]
Current Advances, Research Needs and Gaps in Mycotoxins Biomonitoring under the HBM4EU-Lessons Learned and Future Trends.

Toxins (Basel). 2022-11-24

[5]
Toxicokinetics and metabolism of deoxynivalenol in animals and humans.

Arch Toxicol. 2022-10

[6]
Providing Biological Plausibility for Exposure-Health Relationships for the Mycotoxins Deoxynivalenol (DON) and Fumonisin B1 (FB1) in Humans Using the AOP Framework.

Toxins (Basel). 2022-4-13

本文引用的文献

[1]
Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups.

Environ Int. 2021-12

[2]
Mycotoxin Biomarkers of Exposure: A Comprehensive Review.

Compr Rev Food Sci Food Saf. 2018-9

[3]
Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed.

EFSA J. 2017-9-11

[4]
Human Mycotoxin Biomonitoring: Conclusive Remarks on Direct or Indirect Assessment of Urinary Deoxynivalenol.

Toxins (Basel). 2020-2-24

[5]
Mycotoxin exposure assessments in a multi-center European validation study by 24-hour dietary recall and biological fluid sampling.

Environ Int. 2020-4

[6]
The Norwegian biomonitoring study from the EU project EuroMix: Levels of phenols and phthalates in 24-hour urine samples and exposure sources from food and personal care products.

Environ Int. 2019-8-27

[7]
Biomonitoring of Deoxynivalenol and Deoxynivalenol-3-glucoside in Human Volunteers: Renal Excretion Profiles.

Toxins (Basel). 2019-8-8

[8]
Exposure assessment of Portuguese population to multiple mycotoxins: The human biomonitoring approach.

Int J Hyg Environ Health. 2019-6-26

[9]
Determination of multiple mycotoxins in paired plasma and urine samples to assess human exposure in Nanjing, China.

Environ Pollut. 2019-3-1

[10]
Prediction of deoxynivalenol toxicokinetics in humans by in vitro-to-in vivo extrapolation and allometric scaling of in vivo animal data.

Arch Toxicol. 2018-5-17

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