Castagna Fabio, Piras Cristian, Palma Ernesto, Musolino Vincenzo, Lupia Carmine, Bosco Antonio, Rinaldi Laura, Cringoli Giuseppe, Musella Vincenzo, Britti Domenico
Department of Health Sciences, University of Catanzaro Magna Græcia, CISVetSUA, 88100 Catanzaro, Italy.
Nutramed S.c.a.r.l. Complesso Ninì Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy.
Vet Sci. 2021 Oct 15;8(10):237. doi: 10.3390/vetsci8100237.
Resistance to anthelmintic drugs in gastrointestinal nematodes (GIN) of sheep is of high concern for livestock production worldwide. In Calabria (southern Italy), many plants have been used in ethnoveterinary medicine for parasite control in small ruminants. Here, we present an in vivo evaluation of anthelmintic efficacy of three plant extracts. The first was based on bark and leaves of , the second and the third were based on the whole plant and whole fruit (seeds and peel) of , respectively. Anthelmintic efficacy was evaluated according to the fecal egg count reduction test (FECRT) performed with the FLOTAC technique. The results showed a significant anthelmintic effect of macerate (50%), a low effectiveness of the macerate (20%), and a complete ineffectiveness of macerate (0.1%). With these outcomes, we report a -based remedy reducing 50% GIN egg output. This result was obtained without using any synthetic drug, paving the way for the employment of green veterinary pharmacology (GVP) as a complementary and sustainable method to reduce the use of chemicals and to counteract anthelmintic resistance.
绵羊胃肠道线虫（GIN）对驱虫药产生抗药性是全球畜牧业高度关注的问题。在意大利南部的卡拉布里亚，许多植物已被用于民族兽医学中控制小型反刍动物的寄生虫。在此，我们对三种植物提取物的驱虫效果进行了体内评估。第一种基于[植物名称1]的树皮和叶子，第二种和第三种分别基于[植物名称2]的全株和全果（种子和果皮）。根据使用FLOTAC技术进行的粪便虫卵计数减少试验（FECRT）评估驱虫效果。结果显示，[植物名称1]浸剂有显著驱虫效果（50%），[植物名称2]浸剂效果较低（20%），[植物名称3]浸剂完全无效（0.1%）。基于这些结果，我们报告了一种基于[植物名称1]的疗法可减少50%的GIN虫卵排出量。这一结果是在未使用任何合成药物的情况下获得的，为采用绿色兽医药理学（GVP）作为减少化学药物使用和对抗驱虫药抗药性的补充性可持续方法铺平了道路。
