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甲型 H1N1 流感大流行对季节性流感疫苗体液免疫应答的影响。

Influence of the H1N1 influenza pandemic on the humoral immune response to seasonal flu vaccines.

机构信息

Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, United States of America.

Department of Infectious Diseases, University of Georgia, Athens, Georgia, United States of America.

出版信息

PLoS One. 2021 Oct 22;16(10):e0258453. doi: 10.1371/journal.pone.0258453. eCollection 2021.

DOI:10.1371/journal.pone.0258453
PMID:34679115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8535392/
Abstract

In this study, we hypothesized that the humoral response to trivalent seasonal influenza virus vaccines was influenced by rapid antigenic switching of H1 HA. We tested archived sera and peripheral blood mononuclear cells (PBMC) collected at prior to vaccination at day 0, as well as days 30 and 90 after vaccination during the 2009/2010 and 2010/2011 influenza virus seasons. During the 2009/2010 season, vaccination successfully induced antibodies with hemagglutinin inhibition (HAI) activity against both H1N1 and H3N2 vaccine components. For the 2010/2011 season, the A/California/04/2009 (CA/09) H1N1 elicited seroconversion (HAI titer = 1:40) and novel memory B cell (Bmem) responses from most individuals. However, the H3N2 influenza virus component of the vaccine, A/Perth/16/2009 (Perth/09), back-boosted and elicited antibodies with HAI activity and Bmem response to historical H3N2 influenza virus strains. Following stratification of the pre-existing antibody with HAI against the CA/09 H1N1, there was a negative correlation with HAI seroconversion to other vaccine strains. Overall, strong immune responses against CA/09 H1N1 influenza virus negatively influenced the induction of novel humoral responses.

摘要

在这项研究中，我们假设三价季节性流感病毒疫苗的体液反应受到 H1 HA 的快速抗原转换的影响。我们检测了在 2009/2010 年和 2010/2011 年流感季节之前在接种疫苗的第 0 天、第 30 天和第 90 天收集的存档血清和外周血单核细胞 (PBMC)。在 2009/2010 年季节，疫苗接种成功地诱导了具有血凝素抑制 (HAI) 活性的针对 H1N1 和 H3N2 疫苗成分的抗体。对于 2010/2011 年季节，A/California/04/2009 (CA/09) H1N1 引起了大多数个体的血清转化（HAI 滴度 = 1:40）和新的记忆 B 细胞（Bmem）反应。然而，疫苗中的 H3N2 流感病毒成分 A/Perth/16/2009 (Perth/09) 回补并引发了具有 HAI 活性和针对历史 H3N2 流感病毒株的 Bmem 反应的抗体。在对 CA/09 H1N1 的 HAI 预先存在抗体进行分层后，与其他疫苗株的 HAI 血清转化率呈负相关。总体而言，针对 CA/09 H1N1 流感病毒的强烈免疫反应对新型体液反应的诱导产生了负面影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49e/8535392/a5e64bbf2fed/pone.0258453.g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49e/8535392/7d4ea61342b3/pone.0258453.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49e/8535392/eb40f31a1394/pone.0258453.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49e/8535392/9650abf02804/pone.0258453.g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49e/8535392/a5e64bbf2fed/pone.0258453.g006.jpg

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Immunodominance hierarchy of influenza subtype-specific neutralizing antibody response as a hurdle to effectiveness of polyvalent vaccine.流感亚型特异性中和抗体反应的免疫优势层次，是多价疫苗有效性的障碍。
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