Choi Yoon Seok, Baek Yun Hee, Kang Wonseok, Nam Seung Joo, Lee Jino, You Sooseong, Chang Dong-Yeop, Youn Jong-Chan, Choi Young Ki, Shin Eui-Cheol
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, 335 Gwahangno, Daejeon, Republic of Korea 305-701.
Clin Vaccine Immunol. 2011 Sep;18(9):1519-23. doi: 10.1128/CVI.05053-11. Epub 2011 Aug 3.
The vaccination program against the 2009 pandemic H1N1 influenza virus (2009 H1N1) provided a unique opportunity to determine if immune responses to the 2009 H1N1 vaccine were affected by a recent, prior vaccination against seasonal influenza virus. In the present study, we studied the immune responses to the 2009 H1N1 vaccine in subjects who either received the seasonal influenza virus vaccination within the prior 3 months or did not. Following 2009 H1N1 vaccination, subjects previously given a seasonal influenza virus vaccination exhibited significantly lower antibody responses, as determined by hemagglutination inhibition assay, than subjects who had not received the seasonal influenza virus vaccination. This result is compatible with the phenomenon of "original antigenic sin," by which previous influenza virus vaccination hampers induction of immunity against a new variant. Our finding should be taken into account for future vaccination programs against pandemic influenza virus outbreaks.
2009年甲型H1N1流感大流行病毒（2009 H1N1）疫苗接种计划提供了一个独特的机会，来确定对2009 H1N1疫苗的免疫反应是否受到近期之前接种季节性流感病毒疫苗的影响。在本研究中，我们研究了在之前3个月内接种过季节性流感病毒疫苗或未接种过的受试者对2009 H1N1疫苗的免疫反应。2009 H1N1疫苗接种后，通过血凝抑制试验测定，先前接种过季节性流感病毒疫苗的受试者的抗体反应明显低于未接种过季节性流感病毒疫苗的受试者。这一结果与“原始抗原罪”现象相符，即先前的流感病毒疫苗接种会阻碍针对新变种的免疫诱导。我们的发现应在未来针对大流行性流感病毒爆发的疫苗接种计划中予以考虑。
