Division of Experimental Allergy and Immunodermatology, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Division of Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
J Eur Acad Dermatol Venereol. 2022 Mar;36(3):365-372. doi: 10.1111/jdv.17764. Epub 2021 Nov 12.
S1P is a pleotropic sphingolipid signalling molecule that acts through binding to five high-affinity G-protein coupled receptors. S1P-signaling affects cell fate in a multitude of ways, e.g. influencing cell differentiation, proliferation, and apoptosis, as well as playing an important role in immune cell trafficking. Though many effects of S1P-signaling in the human body have been discovered, the full range of functions is yet to be understood. For inflammatory skin diseases such as atopic dermatitis and psoriasis, evidence is emerging that dysfunction and imbalance of the S1P-axis is a contributing factor. Multiple studies investigating the efficacy of S1PR modulators in alleviating the severity and symptoms of skin conditions in various animal models and human clinical trials have shown promising results and validated the interest in the S1P-axis as a potential therapeutic target. Even though the involvement of S1P-signalling in inflammatory skin diseases still requires further clarification, the implications of the recent findings may prompt expansion of research to additional skin conditions and more S1P-axis modulatory pharmaceuticals.
S1P 是一种具有多种功能的鞘脂信号分子，通过与五个高亲和力的 G 蛋白偶联受体结合发挥作用。S1P 信号转导通过多种方式影响细胞命运，例如影响细胞分化、增殖和凋亡，并在免疫细胞迁移中发挥重要作用。尽管已经发现了 S1P 信号在人体中的许多作用，但 S1P 轴的全部功能仍有待理解。对于特应性皮炎和银屑病等炎症性皮肤病，有证据表明 S1P 轴的功能障碍和失衡是一个促成因素。多项研究调查了 S1PR 调节剂在缓解各种动物模型和人体临床试验中皮肤状况严重程度和症状的疗效，结果显示出有希望的结果，并验证了 S1P 轴作为潜在治疗靶点的兴趣。尽管 S1P 信号在炎症性皮肤病中的作用仍需要进一步阐明，但最近的发现可能会促使研究扩展到其他皮肤疾病和更多的 S1P 轴调节药物。
