Juli Giada, Juli Luigi
Mental Health Department, Catanzaro, Italy.
Psychiatr Danub. 2015 Sep;27 Suppl 1:S383-90.
Epidemiological studies strongly suggest that genetic factors operate at all steps of addictions, including vulnerability to initiation, continued use, and propensity to become dependent. Several studies have been popular to investigate the relative contributions of genetic and environmental factors, including the availability of and exposure to a substance, and shared and unique environments. The genetic influence on addiction has proved to be substantial, and heritabilities for most addictive disorders are moderate to high. In this work we evaluate the current status of data that analyzed genetic contribution in addictions.
流行病学研究有力地表明，遗传因素在成瘾的各个阶段都起作用，包括开始使用的易感性、持续使用以及成瘾的倾向。已有多项研究致力于调查遗传和环境因素的相对作用，包括物质的可获得性和接触情况，以及共享环境和独特环境。事实证明，遗传因素对成瘾的影响很大，大多数成瘾性疾病的遗传度为中度到高度。在这项工作中，我们评估了分析成瘾中遗传作用的数据的现状。
