Xiao Jianxin, Khan Muhammad Zahoor, Ma Yulin, Alugongo Gibson Maswayi, Ma Jiaying, Chen Tianyu, Khan Adnan, Cao Zhijun
Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Faculty of Veterinary and Animal Sciences, The University of Agriculture, Dera Ismail Khan 29050, Pakistan.
Antioxidants (Basel). 2021 Sep 29;10(10):1555. doi: 10.3390/antiox10101555.
Dairy cattle experience health risks during the periparturient period. The continuous overproduction of reactive oxygen species (ROS) during the transition from late gestation to peak lactation leads to the development of oxidative stress. Oxidative stress is usually considered the main contributor to several diseases such as retained placenta, fatty liver, ketosis, mastitis and metritis in periparturient dairy cattle. The oxidative stress is generally balanced by the naturally available antioxidant system in the body of dairy cattle. However, in some special conditions, such as the peripariparturient period, the natural antioxidant system of a body is not able to balance the ROS production. To cope with this situation, the antioxidants are supplied to the dairy cattle from external sources. Natural antioxidants such as selenium and vitamin E have been found to restore normal health by minimizing the harmful effects of excessive ROS production. The deficiencies of Se and vitamin E have been reported to be associated with various diseases in periparturient dairy cattle. Thus in the current review, we highlight the new insights into the Se and vitamin E supplementation as antioxidant agents in the health regulation of periparturient dairy cattle.
奶牛在围产期会面临健康风险。从妊娠后期到泌乳高峰期过渡期间，活性氧（ROS）持续过量产生会导致氧化应激的发展。氧化应激通常被认为是围产期奶牛发生诸如胎衣不下、脂肪肝、酮病、乳腺炎和子宫炎等多种疾病的主要原因。氧化应激一般由奶牛体内天然存在的抗氧化系统来平衡。然而，在某些特殊情况下，如围产期，机体的天然抗氧化系统无法平衡ROS的产生。为应对这种情况，需从外部给奶牛补充抗氧化剂。已发现天然抗氧化剂如硒和维生素E可通过将过量ROS产生的有害影响降至最低来恢复正常健康状态。据报道，硒和维生素E的缺乏与围产期奶牛的各种疾病有关。因此，在本综述中，我们重点介绍了在围产期奶牛健康调节中作为抗氧化剂补充硒和维生素E的新见解。
