Abnormalities of coagulation, platelet function, and fibrinolysis associated with syndromes of insulin resistance.

Insulin resistance that accompanies obesity, hypertension, polycystic ovary syndrome, and the early phases of type 2 diabetes is characterized by a prothrombotic state. The prothrombotic state is a reflection of the direct effects of hyperinsulinemia and associated metabolic abnormalities (postprandial hyperglycemia, increased free fatty acids, and hypertriglyceridemia) on platelets, coagulation, and fibrinolysis. Therapies that improve insulin sensitivity and thereby decrease insulin resistance, hyperinsulinemia, and metabolic abnormalities decrease the prothrombotic state.