Schneider David J
University of Vermont, Burlington, Vermont 05446, USA.
Coron Artery Dis. 2005 Dec;16(8):473-6. doi: 10.1097/00019501-200512000-00003.
Insulin resistance that accompanies obesity, hypertension, polycystic ovary syndrome, and the early phases of type 2 diabetes is characterized by a prothrombotic state. The prothrombotic state is a reflection of the direct effects of hyperinsulinemia and associated metabolic abnormalities (postprandial hyperglycemia, increased free fatty acids, and hypertriglyceridemia) on platelets, coagulation, and fibrinolysis. Therapies that improve insulin sensitivity and thereby decrease insulin resistance, hyperinsulinemia, and metabolic abnormalities decrease the prothrombotic state.
肥胖、高血压、多囊卵巢综合征以及2型糖尿病早期阶段所伴随的胰岛素抵抗，其特征是处于血栓前状态。血栓前状态反映了高胰岛素血症及相关代谢异常（餐后高血糖、游离脂肪酸增加和高甘油三酯血症）对血小板、凝血和纤溶的直接影响。改善胰岛素敏感性从而降低胰岛素抵抗、高胰岛素血症和代谢异常的疗法，可减轻血栓前状态。
