San Diego Lauren, Hogue Taylor, Hampton-Marcell Jarrad, Carroll Ian M, Purdom Troy, Colleran Heather, Cook Marc D
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA.
Department of Kinesiology, North Carolina Agriculture and Technical State University, Greensboro, NC 27411, USA.
Nutrients. 2025 Apr 21;17(8):1392. doi: 10.3390/nu17081392.
African Americans (AA) are disproportionally affected by hypertension (HTN). Gut microbiome metabolites (e.g., butyrate) may mediate the relationship between the microbiome and blood pressure (BP). Previous research reports a consistent indirect relationship between gut butyrate, a product of gut microbial nutrient fermentation, and BP. Thus, this study assessed the relationship between individual diet intake on BP changes after a butyrate treatment.
AA aged 30-50 with HTN underwent treatment with a blinded placebo (5 mmol) and butyrate enema (80 mmol) with a one-week washout period. Ambulatory BP monitors collected measures up to 24 h post-enema. The Nutrition Data System for Research was used to assess diet and Healthy Eating Index (HEI-2015) scores from diet records. Paired -tests and Kendall's correlation tests determined group differences and relationships between variables ( < 0.05).
Positive correlations were found between other vegetables and 24 h diastolic BP (r = 0.64), daytime diastolic BP (r = 0.68), and MAP (r = 0.72). Positive correlations were also found between 24 h systolic BP and HEI-2015 greens and beans sub-scores (r = 0.64) and 24 h DBP and total vegetables (r = 0.64). Negative correlations were found between nighttime arterial stiffness and total grain intake (r = -0.71).
These data suggest diet impacts BP measures in response to acutely increasing gut butyrate. These results provide preliminary evidence linking food groups, not individual nutrients, with BP outcomes and gut butyrate availability.
非裔美国人（AA）受高血压（HTN）影响的比例过高。肠道微生物群代谢物（如丁酸盐）可能介导微生物群与血压（BP）之间的关系。先前的研究报告了肠道微生物营养发酵产物丁酸盐与血压之间存在一致的间接关系。因此，本研究评估了个体饮食摄入量与丁酸盐治疗后血压变化之间的关系。
年龄在30 - 50岁的患有高血压的非裔美国人接受盲法安慰剂（5 mmol）和丁酸盐灌肠（80 mmol）治疗，洗脱期为一周。动态血压监测仪在灌肠后24小时内收集测量数据。使用研究营养数据系统根据饮食记录评估饮食和健康饮食指数（HEI - 2015）得分。配对t检验和肯德尔相关性检验确定组间差异和变量之间的关系（P < 0.05）。
发现其他蔬菜与24小时舒张压（r = 0.64）、日间舒张压（r = 0.68）和平均动脉压（r = 0.72）之间存在正相关。24小时收缩压与HEI - 2015绿叶蔬菜和豆类子得分（r = 0.64）以及24小时舒张压与总蔬菜量（r = 0.64）之间也存在正相关。发现夜间动脉僵硬度与全谷物摄入量之间存在负相关（r = -0.71）。
这些数据表明饮食会影响因肠道丁酸盐急性增加而产生的血压测量值。这些结果提供了初步证据，将食物类别而非单一营养素与血压结果和肠道丁酸盐可用性联系起来。
