Duan Yu, Shan Ze-Chen, Pang Jiao-Jiao, Chen Yu-Guo
Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, 250000, China.
Chest Pain Center, Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan, 250000, China.
Mil Med Res. 2025 Sep 18;12(1):58. doi: 10.1186/s40779-025-00646-8.
Aldehyde dehydrogenase (ALDH) 2, a mitochondrial enzyme, is the main acetaldehyde dehydrogenase involved in the scavenging of alcohol-derived acetaldehyde and endogenous aldehydes. The ALDH2 mutation affects 560 million East Asians and is closely related to an increased risk of various human diseases. In addition to its well-known function in detoxifying alcohol-derived acetaldehyde and endogenous aldehydes, ALDH2 is implicated in human health through its regulation of autophagic machinery and multiple cell death pathways (e.g., apoptosis, necroptosis, pyroptosis, ferroptosis, and NETosis). This review summarizes the current knowledge of ALDH2 and the regulatory mechanism through which ALDH2 regulates autophagy and cell death. In addition, we outline the potential role of ALDH2 in the regulation of autophagy and cell death during the occurrence and progression of human diseases, aiming to provide a novel theoretical framework for human disease treatment.
乙醛脱氢酶2（ALDH2）是一种线粒体酶，是参与清除酒精衍生的乙醛和内源性醛类的主要乙醛脱氢酶。ALDH2突变影响了5.6亿东亚人，并且与多种人类疾病风险增加密切相关。除了在解毒酒精衍生的乙醛和内源性醛类方面的知名功能外，ALDH2还通过其对自噬机制和多种细胞死亡途径（如凋亡、坏死性凋亡、焦亡、铁死亡和中性粒细胞胞外陷阱形成）的调节作用，对人类健康产生影响。本综述总结了目前关于ALDH2的知识以及ALDH2调节自噬和细胞死亡的调控机制。此外，我们概述了ALDH2在人类疾病发生和发展过程中调节自噬和细胞死亡的潜在作用，旨在为人类疾病治疗提供一个新的理论框架。
