脂肪：质量还是数量？对代谢相关脂肪性肝病（MAFLD）进展而言什么最重要。

Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD).

作者信息

Estévez-Vázquez Olga, Benedé-Ubieto Raquel, Guo Feifei, Gómez-Santos Beatriz, Aspichueta Patricia, Reissing Johanna, Bruns Tony, Sanz-García Carlos, Sydor Svenja, Bechmann Lars P, Maranillo Eva, Sañudo José Ramón, Vázquez María Teresa, Lamas-Paz Arantza, Morán Laura, Mazariegos Marina S, Ciudin Andreea, Pericàs Juan M, Peligros María Isabel, Vaquero Javier, Martínez-Naves Eduardo, Liedtke Christian, Regueiro José R, Trautwein Christian, Bañares Rafael, Cubero Francisco Javier, Nevzorova Yulia A

机构信息

Department of Physiology, Genetics and Microbiology, Faculty of Biology, Complutense University of Madrid, 28040 Madrid, Spain.

Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.

出版信息

Biomedicines. 2021 Sep 22;9(10):1289. doi: 10.3390/biomedicines9101289.

DOI:10.3390/biomedicines9101289

PMID:34680405

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8533605/

Abstract

OBJECTIVES

Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether palm oil is potentially an unhealthy food mainly due to its high content of saturated Palmitic Acid (PA) is a matter of debate. The aim of this study was to test whether qualitative aspects of diet such as levels of PA and the fat source are risk factors for Metabolic Syndrome (MS) and Metabolic Associated Fatty Liver Disease (MAFLD).

METHODS

C57BL/6 male mice were fed for 14 weeks with three types of Western diet (WD): 1. LP-WD-low concentration of PA (main fat source-corn and soybean oils); 2. HP-WD-high concentration of PA (main fat source-palm oil); 3. HP-Trans-WD-high concentration of PA (mainly transfat).

RESULTS

All types of WD caused weight gain, adipocyte enlargement, hepatomegaly, lipid metabolism alterations, and steatohepatitis. Feeding with HP diets led to more prominent obesity, hypercholesterolemia, stronger hepatic injury, and fibrosis. Only the feeding with HP-Trans-WD resulted in glucose intolerance and elevation of serum transaminases. Brief withdrawal of WDs reversed MS and signs of MAFLD. However, mild hepatic inflammation was still detectable in HP groups.

CONCLUSIONS

HP and HP-Trans-WD play a crucial role in the genesis of MS and MAFLD.

摘要

目的

最近，许多国家已经限制甚至禁止了反式脂肪，棕榈油已成为食品制造商的首选替代品。棕榈油是否因其高含量的饱和棕榈酸（PA）而潜在地成为不健康食品，这是一个有争议的问题。本研究的目的是测试饮食的定性方面，如PA水平和脂肪来源是否是代谢综合征（MS）和代谢相关脂肪性肝病（MAFLD）的危险因素。

方法

将C57BL/6雄性小鼠用三种类型的西方饮食（WD）喂养14周：1. LP-WD-低浓度PA（主要脂肪来源-玉米油和大豆油）；2. HP-WD-高浓度PA（主要脂肪来源-棕榈油）；3. HP-Trans-WD-高浓度PA（主要是反式脂肪）。

结果

所有类型的WD均导致体重增加、脂肪细胞增大、肝肿大、脂质代谢改变和脂肪性肝炎。用高PA饮食喂养导致更明显的肥胖、高胆固醇血症、更严重的肝损伤和纤维化。只有用HP-Trans-WD喂养导致葡萄糖不耐受和血清转氨酶升高。短期停用WD可逆转MS和MAFLD的症状。然而，在高PA组中仍可检测到轻度肝脏炎症。